Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Nicholas McGranahan et al

Neoantigen-directed immune escape in lung cancer evolution

Rachel Rosenthal et al.

Differential binding affinity of mutated peptides for MHC class I is a predictor of survival in advanced lung cancer and melanoma.

Ghorani E, Rosenthal R, McGranahan N, Reading JL, Lynch M, Peggs KS, Swanton C, Quezada SA. Ann Oncol.

The function and dysfunction of memory CD8+ T cells in tumor immunity.

Reading JL, Gálvez-Cancino F, Swanton C, Lladser A, Peggs KS, Quezada SA.

Allele-specific HLA loss and immune escape in lung cancer evolution

Nicholas McGranahan et al

Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis

Samra Turajlic et al

The “Achilles' heel” of cancer and its implications for the development of novel immunotherapeutic strategies

Kroopa Joshi et al

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Christopher Abbosh et al