LIFE AT Achilles

At Achilles, we are focused on the development of the next generation of personalised immunotherapies to treat cancer and are dedicated to our patients, who desperately need breakthrough medicines.

We provide extraordinary career opportunities for talented individuals, who will have the opportunity to work with highly experienced leaders in science and business to build an exciting company at the very cutting edge of cancer medicine.

At Achilles you will enjoy a flexible and dynamic working environment that fosters creativity, leadership and teamwork. We offer benefits that include competitive salary and performance related bonus, group pension plan, life assurance, private medical insurance and employee share incentive scheme.

If you have what it takes to help build Achilles into a world class immune-oncology company and would like to become a part of our team, please contact: jobs@achillestx.com.

Achilles is an equal opportunity employer committed to a culturally diverse team.

Recruiters and agents must not forward CVs or candidate details to Achilles or any employee of the Company without an explicit, written request from a member of the HR department. We reserve the right to pursue and hire candidate(s) without any financial obligation to the recruiter if their details, which could reasonably identify them, have been passed to the Company without the explicit, written request of a member of the HR department. The agreement of terms in relation to a specific vacancy does not constitute an explicit request for applicants for other advertised roles or speculative applications.

What Our Team Say

I was attracted to Achilles by the ambition of the science that underlies Achilles’ goal. I enjoy the fast-paced environment of a start-up, encountering new challenges on a daily basis. Achilles has a multicultural and cohesive culture with a very strong sense of purpose.

Eleni Kotsiou

Principal Scientist, Process Development

I joined Achilles because I am interested in developing a cancer immunotherapy product with the aim of taking it to clinic. I really enjoy working within a multidisciplinary team and the variety in my role across process development and manufacturing.

Sam Jide-Banwo

GMP Production Scientist

Open PositionsAt Achilles

QC Scientist

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first products for Non-Small Cell Lung Cancer and Melanoma expected to enter the clinic in 1H 2020.

Role Summary:
We are seeking a bright, enthusiastic and motivated QC scientist, ideally with experience in the a GCLP (good clinical laboratory practice) environment to join our growing multi-disciplinary team and support the development of a next generation personalised cancer medicines.
As a QC scientist you will support the validation and clinical production of Achilles Therapeutics ATMP pipeline at the Royal Free Hospital and work closely with the GMP manufacturing team and product development team to support process engineering activities. If you want to be a part of a well-funded, exciting new start-up, and enjoy playing an active role in supporting the development and clinical manufacture of ATMPs which have the ability to transform the clinical management of cancer, then this is the role for you.

Responsibilities:
• Carrying out QC testing of raw materials, in process controls, and finished product, in line with GMP regulations.
• To assist in the preparation and review of documentation including SOPs and risk assessments to ensure the highest levels of controls and traceability.
• Perform immune monitoring for clinical trials and ensure all activities are undertaken in accordance with GCLP and quality standards.
• Assist in the design and validation of immune monitoring assays using flow cytometry and ELISpot.
• Perform maintenance and calibration of laboratory equipment including flow cytometers.
• To coordinate activities with manufacturing to ensure appropriate and timely sampling and testing of raw materials, in-process samples and finished product.
• Be accountable to the Principal QC Scientist.

Education and Experience:
• MSC in a Biological Science discipline.
• 3 years’ experience in a scientific laboratory role.
• Experience working in a GLP/GCLP regulated environment.
• Experience in human cell isolation, and cell and tissue culture.
• Experience in flow cytometry and ELISpot.
• Experience in assay validation.
• Understanding of GCLP guidelines.
• Strongly focused on quality and safety.
• Have excellent planning and organisational and time management skills.
• Have good communication and interpersonal skills.
• Self-motivated with strong initiative and drive.

This is a permanent position based in London, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Associate Director – IT

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first products for Non-Small Cell Lung Cancer and Melanoma expected to enter the clinic in 1H 2020.

Role Summary:
An excellent opportunity has arisen for an Associate Director -IT who will work across the business to define and implement an IT roadmap to meet the company’s current and future IT needs. This is a strategic yet hands on role requiring someone who can work independently and who can balance priorities and deliver pragmatic solutions quickly. Achilles is at an inflexion of growth with large increase in both headcount (80 currently expected to grow to 300+) and operational and systems complexity. Achilles operates across multiple sites in the UK and is setting up US operations in 2020.

Responsibilities:
• Ownership and accountability for the IT operations and strategy and global IT infrastructure including security, networking, telephony, internal systems, technical support and asset management
• Develop manage and deliver effective IT strategies, including business continuity and disaster recovery plan.
• Evaluate business needs and system functionality, to ensure that IT facilities remain fit for purpose
• Proactively ensure the highest levels of systems and infrastructure availability
• Participate in the design of information and operational support systems, including system testing and be fully hands-on
• Prepare and manage the annual IT budget achieving value for money
• Co-ordinate, manage and review all outsourcing and supplier relationships ensuring service and project delivery is in line with agreed service levels and remains fit for purpose
• Identify and implement technology to innovate, improve key business processes and foster collaborative working across the business
• Manage a consistent platform for all user software, hardware and databases that is stable, secure, reliable and scalable as the business grows
• Document and design new processes/ workflows and communicate clearly difficult concepts to non-technical internal users
• Co-ordinate and oversee staff training on our key systems including the existing programme of cyber awareness training

Education and Experience:
• Experience of working in a fast-moving organisation, ideally undergoing rapid scale up
• Hands on – can troubleshoot and resolve technical issues no matter how small
• Excellent and proven technical skills across Microsoft technologies
• IT Infrastructure and communications proficiency: Microsoft Environments (SharePoint, Windows Server, Exchange, Active Directory), Networking (routing, switching, LAN, WAN)
• A bachelor’s degree preferably in IT or technical discipline or alternatively relevant IT qualifications and experience. Microsoft certified systems engineer / CISCO certified or similar
• Life sciences industry experience is an advantage but not essential
• Excellent spoken and written communication skills with great attention to detail for developing documentation
• Strong time management skills, self-motivated, solution orientated and able to organise own workload
• Good interpersonal skills and relationship builder with the ability to influence internal and external stakeholders
• Creative and inquisitive with good analytical, critical thinking and problem-solving skills
• Personal drive, tenacity, patience and motivation.
• Flexibility is also required to travel locally, nationally and internationally when required

This is a permanent position, based in initially based in Stevenage but relocating to West London in 2020 with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Senior Scientist

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first products for Non-Small Cell Lung Cancer and Melanoma expected to enter the clinic in 1H 2020.

Role Summary:
We are seeking a motivated, highly talented and creative Senior Scientist. The successful applicant will join a small team within the Process Development department primarily focused on the development of the new generations of T cell therapy products. As a Senior Scientist you will be responsible for establishing strategies to support process development and perform and oversee experimental activities.
The post requires a highly motivated, hard-working and driven individual with extensive experience in immunology, tumour microenvironment, cell culture techniques, multi-colour flow cytometry and immunoassays. Candidates with previous experience in cell therapies are encouraged to apply.
This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Responsibilities:
• Contribute to the design of novel processes to expand neoantigen reactive T cells
• Perform T cell functional assays and other immunoassays to characterise neoantigen reactive T cells
• High-dimensional flow cytometric data analysis.
• Participate in the Process Development team activities and work in close collaboration with other functions of the company (such as Bioinformatics and Clinical Operations)
• Effectively communicate scientific results to a technical and non-technical audience
• Generating suitable SOPs and following established SOPs
• Complete projects, analyse and manage data, prepare reports and presentations appropriate for internal or external parties within agreed timelines

This position requires:
• A PhD in immunology and 3+ years of relevant work experience or equivalent
• Significant hands-on technical experience in cell culture, flow cytometry and T cell functional assays and in-depth characterisation of immune cells
• Good knowledge of cancer immunology
• Strong sense of urgency and ability to work in a fast-paced environment, excellent planning, organisational and time management skills, and attention to detail
• Dependable and willing to take ownership and responsibility
• Good communication and interpersonal skills

In addition to the above, you are expected to have:
• Experience working with patient blood and tissue samples
• Demonstrable excellence in problem solving within fixed timelines
• Flexibility and the ability to effectively manage multiple concurrent projects

This is a permanent position, based in initially based in Stevenage but relocating to West London in 2020 with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Computational Biologist

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first products for Non-Small Cell Lung Cancer and Melanoma expected to enter the clinic in 1H 2020.

Role Summary:
We are seeking a highly talented and creative Computational Biologist. The successful applicant will join a small team primarily focused on improving and developing methods to identify neoantigens. You will be expected to proficiently identify and benchmark published tools as well as contribute to the development of novel strategies. You will also design, implement, and apply statistical techniques to analyse and integrate large datasets and work in close collaboration with biologists and clinicians to interpret your analysis results.
In this role, you will have ownership and responsibility for leading large-scale projects focused on delivering creative solutions to challenges across the business. You will have the opportunity to work with creative freedom and utilise innovative technologies.
This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

Responsibilities:
• Integration and exploratory data analysis of large, complex datasets
• Develop and test hypotheses whilst prototyping analytical approaches/models
• Develop scalable tools
• Effectively communicate analyses to a technical and non-technical audience

Personality Profile:
• Drive
• Resilience
• Creativity
• Ownership

This position requires (Essential):
• PhD
• Experience in bioinformatics, computational biology, or equivalent
• Demonstrated fluency in R and Python
• Experience of advanced statistical modelling
• Experience of Machine learning concepts
• Good knowledge of molecular genomics and immunology

Preferred experiences:
• Practical experience of analysing next generation sequencing data (DNA and RNA)
• Authorship on high-quality papers in peer-reviewed journals
• Experience in reproducible research practices (e.g. dynamic documents, version control, containerization & workflow engines)
• Extensive knowledge of UNIX based operating systems
• Practical experience of oncogenomic, immunogenomic, neoantigen and/or TCR-seq analyses
• Practical experience with cloud-based technologies

This is a permanent position, based in London, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Biostatistician

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first products for Non-Small Cell Lung Cancer and Melanoma expected to enter the clinic in 1H 2020.

Role Summary:
Achilles Therapeutics is looking for an ambitious and skilled Biostatistician to join our Translational Science team. This team is responsible for the development and delivery of analyses that turn exploratory hypotheses into actionable insights from our clinical trials.
The Biostatistics role at Achilles will be pivotal for delivering robust statistical analyses to evaluate exploratory hypotheses in our Translational Science program.
This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Responsibilities:
• Work within the multidisciplinary Translational Science team and forge strong links with other teams at Achilles to facilitate best practice for the analysis of our biological datasets.
• Model and integrate biological datasets from a variety of sources (e.g. NGS, proteomics and Flow Cytometry) to evaluate our existing hypotheses and guide the future direction of the Translational project.

This position requires:
• Recent PhD (or MSc and 2+ years of relevant work experience) in Biostatistics, or Bioinformatics with a high component of statistical training
• Demonstratable experience in handling, modelling and drawing inferences from large volumes of biological datasets
• Authorship on high-quality papers in peer-reviewed journals
• Demonstrated fluency in either R or Python
• Knowledge of UNIX based operating systems and prior use of cloud computing resources
• Very strong communication skills in order to convey statistical analyses
• Exceptional time management agility to manage concurrent projects
• A clear ability to develop robust data analyses to fixed timescales

This is a permanent position, based in London, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Bioprocessing Engineer

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first products for Non-Small Cell Lung Cancer and Melanoma expected to enter the clinic in 1H 2020.

Role Summary:
We are seeking a bright, motivated and enthusiastic Bioprocess Engineer with experience in immunological cell culture and associated laboratory techniques. As Bioprocess Engineer, you will report directly to the Senior Bioprocess Engineer and Senior Process Validation Scientist, working on collaborative projects which will help to automate and scale our clinical manufacture process. You may also work closely with the Manufacturing and Process Development teams, translating and transforming investigative research-scale projects into GMP.
This is a unique opportunity to work with a leading team of scientists and engineers with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project designed to revolutionise the clinical management of cancer.
This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Responsibilities:
• Immunological cell culture
• Carry out immunoassays including multi-parameter flow cytometry and ELISpot
• Design, optimise and develop assays to characterise Achilles cNeT product
• Generate SOPs in accordance with existing standards
• Support planning and execution of verification and validation activities
• Effectively communicate results, and implications, to technical and non-technical audiences
• Work on collaborative projects to automate clinical manufacture process, including use of devices and bioreactors
• Complete projects, analyse and manage data, prepare reports and presentations appropriate for internal or external parties within agreed timelines

This position requires:
• Undergraduate/Master’s degree in Biochemical/Bioprocess Engineering or Biotechnology.
• laboratory/industry experience.
• Experience developing/translating processes suitable for GMP manufacture.
• In-depth knowledge of immunology/ATMPs/Cell therapies
• Experience with Cell Therapy bioprocessing, including development and/or manufacture.
• Hands-on experience with closed-system bioreactors and/or devices for bioprocess automation and scale-up
• Demonstratable process development/problem solving skills
• Excellent planning, organisational and time management skills, with a proven ability to work in a fast-paced environment.
• Excellent communication and interpersonal skills

This is a permanent position, based in London, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Junior Project Manager

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first products for Non-Small Cell Lung Cancer and melanoma expected to enter the clinic in 1H 2020.

Role Summary:
You will be joining a growing, London based, biotech company which is developing neo-antigen therapy for oncology indications. You would become one of the leaders within their close-knit team, responsible for coordinating and managing allocated studies. Ideal for a LCRA, UK CTM or aCPM/jCPM making the transition into cell therapy from Biotech who already has early phase oncology and or cell therapy experience.
This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.
Play a pivotal role in our Clinical Operations team leading clinical studies within a programme. Act as an expert in your therapy area, working independently and then supported as necessary based on an individual development plan.
This position will have key relationships with internal stakeholders within the clinical project team and will have clearly defined responsibilities working alongside the sCPM, as well as externally with KOLs, investigators and external service providers/vendors.

Responsibilities:
• Create/Review patient consent forms and provide relevant opinion
• Have responsibility for delivery of components of clinical trials
• The overall efficient day-to-day clinical trial management of studies
• Manage and support start up activities for UK clinical trials sites including negotiation of contracts, site selection and review of essential regulatory documentation
• Manage timeline adherence, site budget adherence in conjunction with the sCPM and project quality deliverables
• Interact with and day to day management of vendors including supporting sCPM with vendor budget oversight
• Manage contract requirements
• Perform occasional interim monitoring visits, including site qualification, initiation and close-out, including the source data verification of CRFs and Data clarification forms as stipulated
• Co-ordinate the preparation and publication of data, reports and information, ensuring that these meet legislative, contractual and ethical requirements
• To maintain Project documents in accordance with ICH-GCP and company SOPs and support the transition from paper to eTMF
• Develop and update with oversight of the sCPM study plans and documents, including the Project Plan, Monitoring Plan, Deviation Plan
• Collaborate with site teams and CRAs to drive recruitment and high quality data collection
• Prepares and support material preparation for external meetings, other study trainings and project meetings as required
• Be prepared to travel nationally for the role

This position requires:
• Strong clinical study experience in Oncology and or cell therapy.
• Excellent collaboration and communication skills.
• Knowledge of medical terminology and clinical patient management. ICH GCP trained.
• UK clinical trial experience in a senior or lead role
• Previous experience of site monitoring in early phase oncology studies ideally in melanoma or NSCLC
• Experience with ATIMPs an advantage
• Bachelor’s degree (BSc, BA or RN equivalent) in biological or science-related field is essential
• Skills/Specialist knowledge
• Thorough knowledge of ICH-GCP guidelines and UK legislation.

This is a permanent position, based in London, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Senior Scientist

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first products for Non-Small Cell Lung Cancer and melanoma expected to enter the clinic in 1H 2020.

Role Summary:
We are seeking a motivated, highly talented and creative Senior Scientist. The successful applicant will join a small team within the Process Development department primarily focused on the development of the new generations of T cell therapy products. As a Senior Scientist you will be responsible for establishing strategies to support process development and perform and oversee experimental activities.
The post requires a highly motivated, hard-working and driven individual with extensive experience in immunology, cell therapy, cell culture techniques, multi-colour flow cytometry and immunoassays. Candidates with previous experience in process development and cell therapies are encouraged to apply.
This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Responsibilities:
• Contribute to the design of novel processes to expand neoantigen reactive T cells
• Perform T cell functional assays and other immunoassays to characterise neoantigen reactive T cells
• Participate in the Process Development team activities and work in close collaboration with other functions of the company (such as Bioinformatics and Clinical Operations)
• Effectively communicate scientific results to a technical and non-technical audience
• Generating suitable SOPs and following established SOPs
• Complete projects, analyse and manage data, prepare reports and presentations appropriate for internal or external parties within agreed timelines

This position requires:
• A PhD in immunology and 3+ years of relevant work experience or equivalent
• Significant hands-on technical experience in small- and large-scale immune cell isolation, cell culture, flow cytometry and T cell functional assays
• High dimensional flow cytometric data analysis
• Good knowledge of cancer immunology
• Strong sense of urgency and ability to work in a fast-paced environment, excellent planning, organisational and time management skills, and attention to detail
• Dependable and willing to take ownership and responsibility
• Good communication and interpersonal skills

In addition to the above, you are expected to have:
• Experience working with patient blood and tissue samples
• Demonstrable excellence in problem solving within fixed timelines
• Flexibility and the ability to effectively manage multiple concurrent projects

This is a permanent position, based in initially based in Stevenage but relocating to West London in 2020 with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Head of Clinical Operations US

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first products for Non-Small Cell Lung Cancer and melanoma expected to enter the clinic in 1H 2020.

Role Summary:
We are seeking a Head of Clinical Operations to establish and build operations through North America. The Head of Clinical Operations (US) is responsible for the delivery of the clinical development program (initially two studies with scope to build out further studies) to agreed budget timelines and quality metrics. The person will also lead data management activities across programs to ensure that clinical outputs are of consistently high quality.

Responsibilities:
• Work closely with the VP, Clinical Operations and Director Clinical Operations EU.
• Responsible for the delivery of the clinical development program initially two studies with scope to build out further studies
• Lead data management activities across programs to ensure that clinical outputs are of consistently high quality
• Ensure compliance in all aspects of tissue procurement shipment and storage and ATIMP management and delivery for clinical trials in North America
• Direct line management accountabilities to build a team including clinical project managers, CRAs and CTAs, and will ensure adherence to established guidelines, standards and SOPs. The Head of Clinical Operations will ensure that individual clinical projects are adequately resourced in conjunction with the VP, clinical operations
• A senior member of the Clinical Operations Team
• Ensure adherence to GCP and other rules/regulations as appropriate
• Ensure Vendor contracts are “workable” and accurate. Ensure in-house tracking systems
• Work with a Quality manager (consultant or in-house) to ensure SOPs, forms & templates are ready and current for clinical use
• Support CPMs for processes of Site level approvals /Ethics/MHRA submission and maintenance (UK and EU)
• CT management plans – ensure current and fit for purpose
• Performing Site initiations (where required), overseeing clinical trial and escalation point for vendors by CPM
• Oversee the process of Serious Adverse Events, ensuring medical review and reporting requirements are met
• Vendor assessment and selection in conjunction with VP Clinical Ops
• Oversee and ensure contract process for vendors and study sites, supporting the CPM for the indication
• Co-ordinate and lead CPMs for preparation and publication of data, reports and information, ensuring that these meet legislative, contractual and ethical requirements.

This position requires:
• Knowledge and/or experience with cellular therapies preferred
• Science, medical or pharmacy degree in relevant discipline at BSc level or higher
• At least five years of experience in clinical trial management, preferably in a biotechnology environment
• Experience with cellular therapy, individualized therapy, and/or ATMPs (desirable)
• Experience working in Oncology trials
• Proven experience in clinical trial management in a relevant organisation
• Demonstrated ability to manage early phase clinical trials
• Experienced in working with a CRO, and being responsible for oversight, support on routine events to the CPM in tasks assigned to the CRO
• Judgement and problem-solving abilities to identify solutions to routine issues and seek guidance on more complex issues
• Strong interpersonal skills with ability to build consensus and work effectively in teams

This is a permanent position, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Purchase Ledger Assistant

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 1H 2020.

Role Summary:
We are seeking a highly motivated and positive thinking to act as Purchase Ledger Assistant. You will be responsible for processing supplier invoices and staff expenses. This will involve liaising closely with all parts of the business to ensure appropriate approvals are in place as well interacting with key suppliers to resolve queries. The Purchase Ledger Assistant will provide an indispensable service to the finance team and business and will underpin business critical systems and processes.
This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Responsibilities:
• Maintaining the purchase ledger in Netsuite including inputting all supplier transactions and staff expenses.
• Ensuring all invoices and expenses are authorised in line with Company policy and accounted for in line with accounting standards and VAT rules.
• Liaising with company suppliers, setting up new suppliers and reconciling monthly supplier statements.
• Matching invoices to purchase orders and goods in notes on the online purchasing system.
• Preparing regular payment runs.
• Undertaking any other reasonable duties, commensurate with the job title, as may be determined by their line manager.

This position requires:
Essential
• Previous experience and the ability to demonstrate appropriate skills and knowledge
• Excellent numeracy with an ability to spot numerical errors
• Good verbal and written communication skills
• Intermediate excel skills with experience of maintaining spreadsheets
Desirable
• Netsuite experience
• Good understanding of VAT
• Experience of working in life sciences and biotech

Personal Attributes:
• Individual of the utmost integrity who commands the respect of others and is able to represent the Finance function
• Attention to detail
• Meticulous and methodical
• Proactive
• Flexible and willing to work in the fast-paced changing environment of an ambitious biotech start up

This is a permanent position, that will be initially based in Stevenage and relocating to West London in 2020, with a competitive salary and benefits package.
Please send your CV with a covering letter by clicking Apply.