LIFE AT Achilles

At Achilles, we are focused on the development of the next generation of personalised immunotherapies to treat cancer and are dedicated to our patients, who desperately need breakthrough medicines.

We provide extraordinary career opportunities for talented individuals, who will have the opportunity to work with highly experienced leaders in science and business to build an exciting company at the very cutting edge of cancer medicine.

At Achilles you will enjoy a flexible and dynamic working environment that fosters creativity, leadership and teamwork. We offer benefits that include competitive salary and performance related bonus, group pension plan, life assurance, private medical insurance and employee share incentive scheme.

If you have what it takes to help build Achilles into a world class immune-oncology company and would like to become a part of our team, please contact: jobs@achillestx.com.

Achilles is an equal opportunity employer committed to a culturally diverse team.

Recruiters and agents must not forward CVs or candidate details to Achilles or any employee of the Company without an explicit, written request from a member of the HR department. We reserve the right to pursue and hire candidate(s) without any financial obligation to the recruiter if their details, which could reasonably identify them, have been passed to the Company without the explicit, written request of a member of the HR department. The agreement of terms in relation to a specific vacancy does not constitute an explicit request for applicants for other advertised roles or speculative applications.

What Our Team Say

I was attracted to Achilles by the ambition of the science that underlies Achilles’ goal. I enjoy the fast-paced environment of a start-up, encountering new challenges on a daily basis. Achilles has a multicultural and cohesive culture with a very strong sense of purpose.

Eleni Kotsiou

Principal Scientist, Process Development

I joined Achilles because I am interested in developing a cancer immunotherapy product with the aim of taking it to clinic. I really enjoy working within a multidisciplinary team and the variety in my role across process development and manufacturing.

Sam Jide-Banwo

GMP Production Scientist

Open PositionsAt Achilles

Receptionist

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies for cancer patients targeting clonal neoantigens protein markers unique to the individual that are expressed on the surface of every cancer cell. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

The Company has initiated a programme of works to fit-out its own 24,000 sq. ft. of space at 245 Hammersmith, London which from Q4 2020 will become the global Head Office with state-of-the-art R&D labs, office and meeting/collaboration space. As the Receptionist at 245 Hammersmith, you will be the first point of contact for the Achilles Head Office, welcoming and greeting all stakeholders into the business including company staff, investors, board members, interview candidates and other visitors and collaborators. Your duties will include offering administrative support across the organisation. You will also coordinate front-desk activities, including distributing correspondence and redirecting phone calls.

To be successful as our Receptionist, you should have a welcoming and engaging personality and be able to represent the Achilles culture and vision to all stakeholders visiting or calling the business. You should also be able to deal with urgent issues in a calm, timely and effective manner, while streamlining office operations. Multitasking and stress management skills are essential for this position. This role may require working in shifts, so flexibility is a plus.

Ultimately, a Receptionist’s duties and responsibilities are to ensure that all visitors and staff are welcomed positively and executes all administrative tasks to the highest quality standards.

This position requires:

  • Undertake front of house duties, including meeting, greeting and welcoming all visitors as soon as they arrive at the office to ensure a superb visitor experience
  • Direct visitors to the appropriate person and office
  • Answer, screen and forward incoming phone calls
  • Ensure the reception area is tidy and presentable, with all necessary stationery and material (e.g. pens, forms and brochures)
  • Provide basic and accurate information in-person and via phone/email
  • Receive, sort and distribute daily mail/deliveries
  • Maintain office security by following safety procedures and controlling access via the reception desk (monitor logbook, issue visitor badges)
  • Order front office supplies and keep inventory of stock
  • Update calendars and schedule meetings
  • Arrange travel and accommodations, and prepare vouchers
  • Keep updated records of office expenses and costs
  • Perform other clerical receptionist duties such as filing, photocopying, transcribing and faxing

In addition to the above, the following skills/experiences are desirable:

  • A friendly and welcoming approach with a Customer service attitude
  • Proven work experience as a Receptionist, Front Office Representative or similar role
  • Proficiency in Microsoft Office Suite
  • Hands-on experience with office equipment (e.g. fax machines and printers)
  • Professional attitude and appearance
  • Solid written and verbal communication skills
  • Ability to be resourceful and proactive when issues arise
  • Excellent organisational skills
  • Multitasking and time-management skills, with the ability to prioritise tasks

This is a fantastic opportunity to join a fast-moving, innovative company that seeks to overturn the treatment paradigm and deliver transformative treatments for cancer patients. We are building a leading biopharmaceutical company with the ambition to be a global leader of a revolution in medicine in which life-threatening diseases are treated by a patient’s own cells.

This is a permanent position, based in Hammersmith, with a competitive salary and benefits package.

 

Please send your CV with a covering letter by clicking Apply.

Assistant Facilities Manager

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies for cancer patients targeting clonal neoantigens: protein markers unique to the individual that are expressed on the surface of every cancer cell. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

The Company has initiated a programme of works to fit-out its own 24,000 sq. ft. of space at 245 Hammersmith Road, London which from Q4 2020 will become the Company head office with state-of-the-art R&D labs, office and meeting/collaboration space. As Assistant Facilities Manager at 245 Hammersmith Road, you will be responsible for assisting in the front-line management of the day to day delivery of FM services at our Head Office. Your responsibilities will include: the management of site based in-house and outsourced resources to deliver both hard and soft services; ensuring the effective delivery and monitoring of planned preventative maintenance programs; and contract management for outsourced services and responding to the ‘reactive’ needs of the Head Office.

This position requires:

  • Responsibility for operational staff management.
  • Liaise with the building management team, laboratory manager and suppliers to deliver against established KPI’s & issue resolution.
  • Budget management within define parameters.
  • Ensure statutory and health & safety compliance for the office.
  • Managing the performance of in-house and out-sourced services to the agreed SLA’S.
  • Quality and performance management of all services including monthly performance reporting and maintenance of the site documents.
  • Responsible for the coordination of emergency procedures.
  • Manage relationships with key stakeholders, through regular communication and formal review meetings.

In addition to the above, the following skills/experiences are desirable:

Previous management experience in a corporate or R&D facilities environment as either the client or service provider.

  • Knowledge, understanding and interest in the principles of facilities management.
  • Demonstrable experience of interfacing with suppliers and landlords’ agents to deliver results as measured against established KPI’s or issue resolution.
  • Demonstrable experience in controlling costs.
  • Experience and knowledge of the management of purchasing and invoicing processes.
  • Experience of managing 3rd party budgets.
  • Demonstrable knowledge of existing Health and Safety legislation and Regulations and their applicability to facilities management.
  • Professional attitude and appearance
  • Solid written and verbal communication skills
  • Ability to be resourceful and proactive when issues arise
  • Excellent organisational skills
  • Multitasking and time-management skills, with the ability to prioritise tasks
  • Customer service attitude
  • IOSH Managing Safely or equivalent.
  • FM qualification – BIFM or equivalent.

This is a fantastic opportunity to join a fast-moving, innovative company that seeks to overturn the treatment paradigm and deliver transformative treatments for cancer patients. We are building a leading biopharmaceutical company with the ambition to be a global leader of a revolution in medicine in which life-threatening diseases are treated by a patient’s own cells.

This is a permanent position, based in Hammersmith, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Principle Production Scientist

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

We are seeking a bright, enthusiastic and motivated Principle Production Scientist with an understanding of immunology to join our growing multi-disciplinary team and support the development of a next generation personalised cancer medicines. As a Principle Production Scientist at Achilles Therapeutics, you will work closely with the product development team to help develop the manufacturing process including translation into the clinic. You will help to set up GMP manufacturing process within the CCGTT clean rooms based at Royal Free Hospital and be responsible for ATMP manufacturing as well as performing QC assays. If you want to be a part of a well-funded, exciting new start-up, and enjoy playing a principal role in helping to develop products which will transform the clinical management of cancer, then this is the role for you.

Responsibilities:

  • Lead the scientific aspects of clinical studies
  • Perform problem-solving of closed system cell culture production processes by identifying and implementing procedures in accordance with GMP and relevant regulatory standards and in accordance with Quality Systems.
  • Develop and implement improvements or changes to production methods, techniques, processes and equipment in order to advance the process optimisation progress.
  • Provide a high level of specialist technical and GMP production knowledge to deliver the technical transfer and validation of equipment, manufacturing processes as well as analytical assays used for in process control and final release from R&D facility to the GMP Production Facility.
  • Lead preparation of GMP compliant documentation for the GMP Facility including, but not limited to IMPD, PSF, BMR, SOP, Change Control, COSHH assessments and Risk assessments.
  • Ensure operational excellence and to exercise good housekeeping.
  • Ensure all manufacturing activities are undertaken in accordance with the production requirements and to current GMP regulatory and quality standards.
  • Oversee performance of in process control and final release analytical assays, analyse and interpret the results.
  • Master high standards in production documentation ensuring that all procedures are documented and reviewed to appropriate quality standard; all records are clear, concise and legible at all times to enable for full repetition and traceability as per Good Documentation Practice (BMR, deviations, OOS, CAPA).
  • Responsible for reporting of any deviations occurring during the manufacturing process and ensure a deviation report is submitted and corrective and preventative actions progressed to completion.

Desirable experience:

  • PhD in a Biological Science discipline.
  • 15 years’ experience in a scientific laboratory role.
  • 5 years’ experience working in a regulated environment (GLP/GCLP/GMP).
  • Experience in human cell culture (patient blood and tissue) in R&D as well as GMP compliant environment.
  • Able to work in a Grade B cleanroom production environment.
  • Process and assay optimisation/development experience.
  • Technical experience in cell isolation, cell/tissue culture, flow cytometry, Elispot assays, T-cell functional assay development and basic molecular biology techniques.
  • Working knowledge of generating data for regulatory submissions.
  • Strongly focused on quality and safety.
  • Have excellent planning and organisational and time management skills.
  • Have good communication and interpersonal skills.
  • Self-motivated with strong initiative and drive.

This is a permanent position, based at Achilles’ manufacturing site at The Royal Free Hospital in London with the opportunity to work with other Achilles departments at Stevenage and Hammersmith. This position offers a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

GMP Quality Manager

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

We are seeking a well-qualified and experienced QA professional to join our growing team at Achilles Therapeutics to support the scale up of manufacturing for the Company’s personalised T cell therapy products for use across Achilles clinical trial programmes. This role will play a key role in establishing, growing and maintaining the quality systems and processes to support the expansion of operations for GMP production. Additionally, ensuring GxP and other regulatory requirements relating to clinical trial manufacture are met and maintained for ATIMPs (Advanced Therapy investigational medicinal product). A hands-on approach is essential, and it is expected that the successful candidate will work with the clinical, regulatory, QC and manufacturing teams to implement and develop key documents.

This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Key Responsibilities:

  • QA review and approval of procedures, Master Batch Records and any other relevant GMP documentation
  • Perform batch documentation review activities
  • Review and Approval of Change Controls
  • Deviation, investigation and Corrective and Preventative Actions (CAPA) management
  • Review and Approve Out of Specification Investigations
  • Work with Teams Across the Business and Externally to Investigate Quality Issues
  • Support Complaints Management Process
  • Support with Qualification & Validation Activities
  • Support the creation, maintenance and continuous improvement of Achilles Quality Management System (QMS)
  • Ensuring compliance with GxP and regulatory requirements including overlap with manufacturing systems relating to manufacturing and clinical trials
  • Support the administration of the company’s document management system
  • Provide advice and guidance to the wider Team
  • Perform internal audits to determine compliance with GMP and identify areas for improvement
  • Perform external audits if necessary
  • Support of the co-ordination of Recall Activities
  • Support of provision of In-house Training Activities
  • Provide support and data for Achilles Quality Management Reviews

This position requires:

  • 3+ Years Working in QA in a Biotech/Biologics/ATMP GMP Environment Ideally on MIA /MIA IMP Licensed Site
  • 3+ Years of Technical Knowledge of Aseptic Manufacturing Processes, Sterility Assurance and Laboratory Techniques
  • Knowledge about Regulatory Requirements for ATIMPs
  • Thorough Understanding of EU and US GMP Requirements
  • 3+ Years’ Experience within a GMP Quality Assurance Department
  • Experience Investigating Deviations, Complaints, Reviewing Change Controls, Implementing CAPAs and Conducting Internal Audits
  • Experience with Batch and Associated Documentation and its Review

In addition to the above, the following skills/experiences are desirable:

  • Understanding of Clinical Trial Directives/Regulations
  • Knowledge of HTA Requirements for Cells and Tissues
  • Experience with Environmental Monitoring and Clean Rooms
  • Experience in a QC GMP Environment
  • Experience with Qualification and Validation Plans, Activities and Reports
  • Experience of Working with Sponsors, Contract Manufacturing Organisations and Contract Testing Laboratories
  • Experience with Document Preparation/Review in Support of Regulatory Submission Packages
  • Experience external auditing
  • Understanding of HTA requirements and Tissues and Cells Directive
  • Experience of training staff and building and managing small team
  • Experience with Clean room and facility design
  • Experience with Clinical manufacturing operations
  • Ability to manage multiple projects and prioritise to support business
  • Ability to work independently with minimal supervision or guidance

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position, based at Achilles’ manufacturing site at The Royal Free Hospital in London with the opportunity to work with other Achilles departments at Stevenage and Hammersmith. This position offers a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Research Collaborations and Operations Manager / Lead

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

The role exists to improve the R&D ecosystem through managing the information flow and internal collaboration from the different parts of R&D and from wider external collaborators.

Reporting to the CSO, Sergio Quezada, this role will attend the R&D Leadership Team as an observer in order to get into the variety of initiatives that are happening across the company.  The role will add value intellectually but also integrationally pulling the different strands of our research together into a cohesive story.

This role demands an ability to work across teams and functions and build relationships with a diverse community of external academics and experts.

Responsibilities:

  • Responsible for facilitating research collaborations between Achilles and external partners
  • To engage, evaluate, establish, manage and report on external research collaborations
  • Whilst reporting to the CSO, the post holder should also be responsible to facilitate research work and reporting across PD, TS and BI under guidance of the VPs of Bioinformatics, Process Development and the Translational Science Team Lead
  • Integrate external research collaborations with internal research

Education and Experience:

  • PhD in immunology
  • Postdoctoral experience in immunology, preferable cancer immunology/immunotherapy
  • Experience in Bioinformatics is desirable
  • Experience in project management and grant/paper writing
  • Able to credibly command the respect and trust of their colleagues. Relationships built through blending scientific knowledge and expertise with an ability to communicate effectively and take people with them
  • A problem solver with a can-do attitude, positive and proactive
  • Builds high-quality working relationships and actively works through influencing and collaboration
  • Strong communicator with both good presentation as well as written communication skills: someone who speaks in plain English and cuts through excessive jargon
  • Flexible – able to adapt and effectively deal with rapidly changing and stressful situations
  • Strong ownership and delivery
  • Highly organised individual with excellent project management skills
  • Sound judgement – knows when to escalate as required
  • Able to work independently coupled with highly developed team and collaboration skills.

This is a permanent position based in London, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Training Manager, Surgical Platforms

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

An exciting opportunity has arisen for a Training Manager to join the Supply Chain Operations Team. The role will form an integral part of the Supply Chain Operations team and will provide support in the management and expansion of the cell therapy supply chain in line with company objectives. The post holder will support and lead on the development and future scaling of the company’s training platform and successful delivery of approved clinical trials in full compliance with SOPs and ICH-GCP.

In this role, you will be responsible for the design, development and implementation of a novel training platform which will be delivered to key external partners. This platform will form the basis of our partnerships with key sites, helping sites deliver protocol procedures  in a safe and effective manner.

The Global Training Manager will be responsible for designing the framework, content and structure to allow for effective training. This includes partnering with Media and Training companies to develop innovative tools and resources which will drive interaction and education.

Achilles are rapidly expanding our clinical programs globally and the Global Training Manager will need to consider how technology can be utilised to effectively communicate with all levels of the healthcare profession in remote locations.

The post holder will need to have experience in project management, timely delivery of company objectives with both internal and external stakeholder management. There will be the need to source and manage external vendors to support operational delivery and overall budget management. The job would ideally suit someone with a healthcare or pharmaceutical/CRO background who is creative and wants to develop in an outward training role or someone from a media or marketing background with interest and knowledge in medicine.

Responsibilities:

  • Work with Supply Chain Manager and SVP Clinical Operations to plan strategy for the design and delivery of Achilles supply chain operations
  • Ensure project deliverables are met according to agreed timelines, schedule and to budget
  • Independently source, select contract and set up external vendors as approved
  • Oversee expansion of the training platform by recruiting and line managing additional team members.
  • Ongoing budget and performance management of chosen vendors reported to SCM
  • Works with key contacts at clinical sites to support training and engagement of KOLs
  • Work independently or with appropriate vendors to produce and maintain high quality training manuals to complement training videos
  • Ensure the supply chain operations are implemented across multiple territories compliantly
  • Develop, maintain and update training materials as required
  • Work autonomously to develop agreed operational plans and deadlines, working with Achilles cross functions as needed
  • Contribute towards building new internal processes and systems within the supply chain operations team
  • Assist with the preparation and distribution of clinical trial supplies
  • Attend regular project team meetings
  • Update CV and training records as required
  • Any other ad-hoc tasks as required
  • Responsible for adhering to all health and safety guidance provided by the company

This is as evolving role and the above list of responsibilities is not exhaustive; the post holder may be requested to assume additional duties, as might reasonably be required. This job description will be reviewed during the annual review process.

Demonstrated Skills and competencies:

  • Minimum of three-years’ experience of working in a healthcare setting or in the pharmaceutical/CRO industry or media and marketing
  • Knowledge of Achilles target indications (desirable)
  • Knowledge of medical procedures in healthcare setting is desirable
  • Batchelor’s degree (BSc, BA or RN equivalent), Ideal in biological or science or media or marketing field
  • Experience of developing and delivering high quality training materials
  • Experience of project management and proven track record of delivering according to agreed project timelines
  • High level of communication is essential (verbal and in writing); ability to communicate effectively within a healthcare setting at every level
  • Able to engage and lead autonomously key discussions with external stakeholders
  • Ability to work effectively with external vendors ensuring key deliverables are met in line with projections
  • Willingness and ability to travel nationally and globally and at short notice for up to 20% of contracted hours
  • Good knowledge of ICH-GCP
  • Self-motivated taking personal pride in delivering on personal and corporate objectives
  • Able to interact effectively with individuals at all levels of the organisation
  • An eye for accuracy and good attention to detail
  • Strong organisational, time management and communication skills
  • Ability to act on own initiative within inter-related team and meet deadlines and dynamic turnaround requirements
  • Microsoft Office skills – excellent proficiency in Word, Excel, PowerPoint and Outlook required

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position, based in Hammersmith, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

 

Engineering Project Liaison

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

We are seeking an ambitious and engaging Engineering Project Liaison to support the Project Director on large GMP capex projects from concept design through to construction, commissioning and validation.

You will have the opportunity to act as the Achilles point of contact with external Project Management companies and drive the deliverables to ensure on time completion.

This varied role will offer great exposure and insight into CAPEX projects whilst helping to develop your technical skills.

This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Responsibilities:

  • Be accountable for project plans and timelines for the GMP capex project
  • Arrange external and internal meetings, prepare meeting agendas, keep detailed minutes and ensure decisions are actioned
  • Attend meetings alongside Achilles Project Director and help shape the project direction
  • Lead follow up activities from meetings
  • Conduct research into solutions – such as identify suppliers and partners who assist the evolution of the project
  • Understand facility engineering and challenge business decisions
  • Document and track operational deliverables for commercial manufacturing projects

This position requires:

  • Degree in a relevant engineering discipline or equivalent
  • Project management qualification
  • Experience of working in a GMP engineering project
  • Excellent interpersonal and organisation skills
  • Ability to work under pressure, prioritise and operate in a fast-paced environment

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position, based in London, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Data Engineer

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

The Translational team is responsible for the development and delivery of data and analyses that turn exploratory hypotheses into actionable insights from our clinical trials. To support the automation of our data and analysis pipeline, we are seeking a talented and proactive Data Engineer to support our data management, reporting and analytical capabilities.

The successful applicant will be expected to possess a strong knowledge and experience of coding and its best practices. Experience working with large and heterogenous datasets is a key requirement, as is the ability to work within a multidisciplinary team.

This position requires:

  • Bachelor’s or Master’s degree in computing science or equivalent experience
  • Prior experience of working as a software or data engineer
  • Experience writing Python/R scripts
  • Ability and eagerness to rapidly learn new languages/frameworks as required.
  • Experience working in a Linux command-line environment
  • Experience with Git version control
  • Experience working with containerisation e.g. Docker

In addition to the above, the following skills/experiences are desirable:

  • Experience with Continuous Integration and R packages/ python modules
  • Knowledge of Data Management best practices
  • Demonstratable experience with processing and visualisation of biological datasets
  • Experience working with the Atlassian toolchain (Jira, Bitbucket, Confluence)
  • Experience working in an Agile/Scrum environment

Successful candidates will also possess good communication skills, a desire to work in a dynamic fast paced multidisciplinary team environment and an ability to manage multiple, concurrent initiatives.

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position, based in Hammersmith, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Biostatistician

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

Achilles Therapeutics is looking for an ambitious and skilled Biostatistician to join our Translational Science team. This team is responsible for the development and delivery of analyses that turn exploratory hypotheses into actionable insights from our clinical trials.

The Biostatistics role at Achilles will be pivotal for delivering robust statistical analyses to evaluate exploratory hypotheses in our Translational Science program.

This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Responsibilities:

  • Work within the multidisciplinary Translational Science team and forge strong links with other teams at Achilles to facilitate best practice for the analysis of our biological datasets.
  • Model and integrate biological datasets from a variety of sources (e.g. NGS, proteomics and Flow Cytometry) to evaluate our existing hypotheses and guide the future direction of the Translational project.

This position requires:

  • Recent PhD (or MSc and 2+ years of relevant work experience) in Biostatistics, or Bioinformatics with a high component of statistical training
  • Demonstratable experience in handling, modelling and drawing inferences from large volumes of biological datasets
  • Authorship on high-quality papers in peer-reviewed journals
  • Demonstrated fluency in either R or Python
  • Knowledge of UNIX based operating systems and prior use of cloud computing resources
  • Very strong communication skills in order to convey statistical analyses
  • Exceptional time management agility to manage concurrent projects
  • A clear ability to develop robust data analyses to fixed timescales

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position, based in London, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Bioinformatics Software Engineer

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

We are seeking a talented and enthusiastic team player to support the robust implementation of features in our bioinformatics software pipeline arising from research findings. This software is a highly specialised pipeline focused on the identification of neo-antigens from high-throughput DNA sequencing data to direct the development of targeted immunotherapies in cancer.

This position requires:

  • One of the following qualifications in Bioinformatics, Computational Biology or a related technical field: PhD; BSc with two years of industrial/academic experience; MSc with one year of industrial/academic experience
  • Extensive expertise in Python, R or a similar scripting language
  • Experience with developing and maintaining bioinformatics pipelines
  • Experience with version control systems such as Git
  • Ability and willingness to rapidly learn new languages/frameworks as required
  • Excellent communication skills
  • A disciplined attitude towards developing robust, reliable and maintainable code

 

In addition to the above, the following skills/ experiences are desirable:

  • Experience writing production-grade code as part of a development team
  • Experience working routinely within a Linux command-line environment and strong knowledge of shell scripting
  • Groovy (or Java) experience
  • Hands-on experience with high-throughput DNA sequencing data

Successful candidates will also possess the ability to take initiative, a desire to work in a dynamic fast paced team environment and an ability to manage multiple, concurrent projects. Prior bioinformatics experience is not required, but a willingness to learn is essential.

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position, initially based in Stevenage but relocating to West London in 2020 with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.