LIFE AT Achilles

At Achilles, we are focused on the development of the next generation of personalised immunotherapies to treat cancer and are dedicated to our patients, who desperately need breakthrough medicines.

We provide extraordinary career opportunities for talented individuals, who will have the opportunity to work with highly experienced leaders in science and business to build an exciting company at the very cutting edge of cancer medicine.

At Achilles you will enjoy a flexible and dynamic working environment that fosters creativity, leadership and teamwork. We offer benefits that include competitive salary and performance related bonus, group pension plan, life assurance, private medical insurance and employee share incentive scheme.

If you have what it takes to help build Achilles into a world class immune-oncology company and would like to become a part of our team, please contact: jobs@achillestx.com.

Achilles is an equal opportunity employer committed to a culturally diverse team.

Strictly no Agencies. Please note that Achilles Therapeutics does not accept speculative applications from recruitment agencies.

What Our Team Say

I was attracted to Achilles by the ambition of the science that underlies Achilles’ goal. I enjoy the fast-paced environment of a start-up, encountering new challenges on a daily basis. Achilles has a multicultural and cohesive culture with a very strong sense of purpose.

Eleni Kotsiou

Principal Scientist, Process Development

I joined Achilles because I am interested in developing a cancer immunotherapy product with the aim of taking it to clinic. I really enjoy working within a multidisciplinary team and the variety in my role across process development and manufacturing.

Sam Jide-Banwo

GMP Production Scientist

Open PositionsAt Achilles

Bioprocess Engineer

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking a bioprocess engineer/scientist with experience in GMP process development to join our growing company and support the development of next generation personalised cancer medicine. As Bioprocess Engineer at Achilles Therapeutics, you will report directly to the Senior Bioprocess Engineer, and work closely with the Manufacturing and Process Development teams to support the development and implementation of novel technologies into our current and future manufacturing pipeline. The successful candidate will play a role in the development and evaluation of novel technologies and devices for improving existing and future manufacturing processes. Activities will encompass both upstream and downstream unit operations, with aspects of both design and biological verification, as well as validation. Previous experience with Cell Therapy bioprocessing would be an advantage.
This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Responsibilities:
• Support the in-house development of novel bioprocessing technologies/solutions.
• Aid in the design and execution of technology verification and validation programmes.
• Process development and GMP translation of both upstream and downstream operations for T cell therapy manufacture.
• Identify and evaluate new technologies for integration into the manufacturing process.
• Additional responsibilities are expected in line with company growth.

This position requires:
• Undergraduate/Master’s degree in Biochemical/Bioprocess Engineering or Biotechnology. Other biological science degrees may be considered where paired with relevant experience.
• 3+ years laboratory/industry experience.
• Experience developing/translating processes suitable for GMP manufacture.
• Experience with Cell Therapy bioprocessing, including development and/or manufacture.
• Novel technology/medical device development experience.
• Computer-aided design skills would be a beneficial.
• Excellent planning, organisational and time management skills.
• Good communication and interpersonal skills.
• Self-motivation with strong initiative and drive.
• Strong problem-solving skillset.

This is a permanent position, based in London, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Cell Therapy Operations Project Manager

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking a well-qualified and experienced candidate to join our growing multi-disciplinary team at Achilles Therapeutics to support the delivery of the Company’s personalised cell therapy product that is entering the clinic later this year in a phase I/II trial. The Cell Therapy Operations Project Manager will be responsible for planning, tracking, management and communicating activities across the Manufacturing, Quality Control and Process Development functions. This will include working with contract testing organisations, collaborators, logistics partners, internal stakeholders and strategic partners. In addition, the role will include responsibility for overseeing the project management of expanding Achilles future manufacturing capabilities.
This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Responsibilities:
• Document and track operational deliverables for CMC timelines
• Lead CMC communications for operational activity to internal stakeholders
• Serve as a primary point of contact with external collaborators on all CMC activities
• Facilitate contingency planning and problem solving to ensure maintenance of CMC timelines
• Co-ordinate and oversee the transfer of the Company’s technology into newly identified GMP facilities
• Organise and chair regular CMC project management meetings
• Work closely with SVP Manufacturing and Head of GMP Production to support operational delivery of CMC milestones

This position requires:
• Proven experience in the biotech/pharma industry working within project management in a CMC function
• MSc or BSc in biological sciences
• Proven relationship management of collaborators and contract testing organisations
• Experience of working within a GMP environment preferably in cell and gene therapy
• Experience of regulatory landscape for advanced therapies
• Excellent interpersonal and organisation skills
• Ability to work under pressure, prioritise and operate in a fast-paced environment
• Outstanding team player

This is a permanent position, based across London and Stevenage with a competitive salary and benefits package.
Please send your CV with a covering letter by clicking Apply.

Senior GCLP Scientist

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking a Senior Scientist with experience working in a GCLP laboratory to join our growing company and support the development of a next generation personalised cancer medicine. As Senior GCLP Scientist at Achilles Therapeutics, you will work as part of the translational science team to oversee GCLP activities at our Stevenage site, working closely with other members of the team to carry out immune monitoring assays for follow-up of clinical trials at Achilles Therapeutics.

The successful candidate will contribute to set up and daily running of the GCLP laboratory at the Stevenage site, including preparation of documentation according to GCLP guidelines and validation and maintenance of equipment, with the aim of applying for accreditation for the laboratory in the future.

The ideal candidate will have strong knowledge of immunoassays including flow cytometry sample preparation and analysis, a background in immunology or cancer immunology, and experience of working in a GCLP-accredited laboratory or in accordance with GCLP guidelines. If you want to be a part of a well-funded, exciting new start-up, and enjoy contributing to development of products which will transform the clinical management of cancer, then this is the role for you.

Responsibilities:
– Liaise with other Achilles members of staff to set up and run the GCLP laboratory
– Prepare documentation, including SOPs and Q&V documents, according to GCLP guidelines
– Establish procedures to ensure sample chain of custody and data integrity
– Validate and carry out a range of immunoassays with a strong focus on flow cytometry
– Validation and maintenance of laboratory equipment
– Enter sample and analysis data into the translational science database
– Assist with reports and data extraction when needed
– Supervise junior GCLP scientists

This position requires:
– Undergraduate degree in a biological subject
– 3+ years hands-on laboratory experience
– Proficiency in multi parameter flow cytometry
– Experience working in a GCLP laboratory or according to GCLP guidelines
– Proficiency with MS Office
– Excellent planning and organisational and time management skills
– Good communication and interpersonal skills
– Self-motivated with strong initiative and drive

Desirable experience:
– Master’s degree in a relevant subject
– Knowledge of cancer biology and immunology
– An understanding of Human Tissue Authority legislation
– Experience working with a LIMS system
– Immunoassay experience eg ELISPOT

This is a permanent position based in Stevenage, with a competitive salary and benefits package to match seniority and experience. The company has laboratories in London and Stevenage UK.

Please send your CV with a covering letter by clicking Apply.

Principal/Head QC Scientist

About Achilles Therapeutics:

Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking a Principal/Head QC Scientist who will lead a small team supporting GMP operations with responsibility for performing all QC related assays for in-process control and final release testing of Achilles T cell therapies (flow cytometric, ELISpot) that are entering the clinic later this year in a phase I/II trial. The candidate will be responsible for developing the strategy of the team with senior members of the company and leading on implementation of all QC documentation and assay validation in line with EU GMP for advanced therapies. In the addition the Principal/Head QC Scientist will lead on supporting both the tech transfer and process development teams on all QC related activity to enable introduction of new manufacturing processes and analytical techniques. As well as developing and growing the team going forward in line with approved budgets.
A hands-on approach is essential, and it is expected that the successful candidate will work with the quality, regulatory and manufacturing teams to implement and develop key documents.
This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Responsibilities:
• Manage Achilles QC activities for tech transfer and manufacture of ATMP
• Perform routine QC duties and prepare documentation to ensure GxP & MHRA compliance plus other regulatory requirements relating to manufacture and clinical trials for cellular therapies and ATIMPs
• Oversee qualification and validation of equipment and assays
• To review analytical and laboratory data for accuracy, completeness and compliance with documented procedures
• Management of QC compendial testing e.g. endotoxin, mycoplasma, sterility and environmental monitoring.
• Manage junior members of the QC team

This position requires:
• BSc or MSc in a biological subject
• 3 years working in a QC and GMP environment, or equivalent experience
• Technical expertise with immunoassays including flow cytometry and ELISpot
• Experience in qualification and validation of equipment and assays
• Experience in preparing SOPs, Qualification and Validation documents, and other related documentation
• Experience of training and managing staff
• English Language skills
• Good working knowledge of Microsoft Office

Desired experience:
• Knowledge of QC compendial testing (endotoxin, mycoplasma and sterility testing)
• Knowledge of biopharmaceutical and cell-based techniques including immunohistochemistry, PCR, DNA/RNA isolation, cytotoxicity and cell Proliferation Assays.

This is a permanent position, based in London with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Bioinformatician

About Achilles Therapeutics:

Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:

We are seeking a highly talented and creative Bioinformatics Scientist. The successful applicant will join a small team primarily focused on improving and developing methods to identify neoantigens. You will be expected to proficiently identify and benchmark published tools as well as contribute to the development of novel strategies. You will also design, implement, and apply statistical techniques to analyse and integrate large datasets and work in close collaboration with biologists and clinicians to interpret your analysis results.
This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This position requires:

• Recent PhD (or MSc and 2+ years of relevant work experience) in bioinformatics, computational biology, or equivalent
• Good knowledge of molecular genomics and immunology
• Knowledge of advanced statistical & machine learning concepts
• Practical experience of analysing next generation sequencing data (DNA and RNA)
• Authorship on high-quality papers in peer-reviewed journals
• Demonstrated fluency in R and Python
• Experience in reproducible research practices (e.g. dynamic documents, version control & containerization)
• Extensive knowledge of UNIX based operating systems

In addition to the above, you are expected to have:

• Exceptional communication skills
• Demonstrable excellence in problem solving within fixed timelines
• Flexibility and the ability to effectively manage multiple concurrent projects

With the following skills/experiences are desirable:

• Practical experience of oncogenomic, neoantigen and TCR-seq analyses
• Practical experience with cloud-based technologies

This is a permanent position, based in the Stevenage Bioscience Catalyst, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

DevOps Engineer / Systems Administrator

About Achilles Therapeutics:

Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:

We are seeking a talented and enthusiastic DevOps Engineer / Systems Administrator to manage the infrastructure required for developing, validating and deploying our bioinformatics platform, PELEUS™, within the AWS cloud computing environment. This software is a highly specialised automated platform focused on the development of targeted immunotherapies in cancer. The role includes both supporting the use of existing infrastructure and implementing new HPC technologies into the bioinformatics framework.

The successful applicant will have experience as a DevOps engineer in a team developing a software product deployed on a cloud computing environment and be familiar with AWS best practices. You will know how to structure resources and code to ensure that the software is robust and efficient. Your responsibilities will include managing the compute infrastructure, optimising compute resources and working closely with the developers to deliver the next generation of our bioinformatics platform.

This position requires:

• 2+ years of Linux system administration experience, at least 1 of which is with AWS systems
• Expertise with a Linux command line interface
• Experience with job-scheduling systems (e.g. SGE, Slurm, AWS Batch)
• Ability to communicate clearly with a technical and non-technical audience
• Professional experience working in a software development team

In addition to the above, the following skills/experiences are desirable:

• Relevant AWS certification – DevOps Engineer, SysOps Administrator, Certified Developer.
• Experience with Git, source code management (e.g. Bitbucket), issue tracking (e.g. Jira) and continuous integration (e.g. Travis CI).
• Groovy (or Java), R and Python experience
• Familiarity with containerisation environments (e.g. Docker)
• Knowledge of bioinformatics pipeline development
• Comfortable working in an Agile environment

Successful candidates will also possess the ability to take initiative, a desire to work in a dynamic fast paced team environment and an ability to manage multiple, concurrent projects. Prior bioinformatics experience is not required, but a willingness to learn is essential.

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position, based in Stevenage, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Senior Bioinformatician

About Achilles Therapeutics:

Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:

We are seeking a highly talented and creative Senior Bioinformatician to join our team and to contribute to the development of the next generation of immune-based cancer therapies.

The successful applicant will join a small team focused on the expansion and further development of an established bioinformatics pipeline for the identification of clonal variants and prediction of neo-antigens from exome-level sequence data. You will be expected to proficiently benchmark published tools as well as develop novel approaches to the analysis and interpretation of exome sequencing data. You will also design, implement, and apply statistical techniques to analyse and integrate large datasets and work in close collaboration with biologists and clinicians to interpret your analysis results.

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immune-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This position requires:

  • PhD in bioinformatics, computational biology, or equivalent and a strong publication record
  • A solid understanding of cancer biology and/or immunology
  • Practical experience of analysing DNAseq data and a broad knowledge of common tools and algorithms
  • Fluent programming skills in R/Bioconductor, Python or Perl

In addition to the above, the following skills/experiences are desirable:

  • Practical experience of in silico neo-antigen detection methods
  • Prior experience analysing RNAseq data
  • Familiarity with software development, version control, and collaboration tools

Successful candidates will also possess good communication skills, a desire to work in a dynamic fast paced team environment and an ability to manage multiple, concurrent initiatives.

This is a permanent position, based in London, with a competitive salary and benefits package.

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Please send your CV with a covering letter by clicking Apply.