LIFE AT Achilles

At Achilles, we are focused on the development of the next generation of personalised immunotherapies to treat cancer and are dedicated to our patients, who desperately need breakthrough medicines.

We provide extraordinary career opportunities for talented individuals, who will have the opportunity to work with highly experienced leaders in science and business to build an exciting company at the very cutting edge of cancer medicine.

At Achilles you will enjoy a flexible and dynamic working environment that fosters creativity, leadership and teamwork. We offer benefits that include competitive salary and performance related bonus, group pension plan, life assurance, private medical insurance and employee share incentive scheme.

If you have what it takes to help build Achilles into a world class immune-oncology company and would like to become a part of our team, please contact: jobs@achillestx.com.

Achilles is an equal opportunity employer committed to a culturally diverse team.

Strictly no Agencies. Please note that Achilles Therapeutics does not accept speculative applications from recruitment agencies.

What Our Team Say

I was attracted to Achilles by the ambition of the science that underlies Achilles’ goal. I enjoy the fast-paced environment of a start-up, encountering new challenges on a daily basis. Achilles has a multicultural and cohesive culture with a very strong sense of purpose.

Eleni Kotsiou

Principal Scientist, Process Development

I joined Achilles because I am interested in developing a cancer immunotherapy product with the aim of taking it to clinic. I really enjoy working within a multidisciplinary team and the variety in my role across process development and manufacturing.

Sam Jide-Banwo

GMP Production Scientist

Open PositionsAt Achilles

eTMF Specialist

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
An excellent opportunity has arisen for an eTMF Specialist, responsible for implementing, owning and managing the eTMF (Electronic Trial Master File) system. We are looking to have the successful candidate in position by the end of 2019.

Responsibilities:
• Work with a selected vendor to set up, implement and maintain an eTMF (Trial Master File);
• Work with third party vendors to ensure that the eTMF platform and electronic data platform is able to be used at scale and fully integrated to meet the business needs.
• Manage and run the eTMF in accordance with the DIA reference model and be responsible for the oversight of compliance alongside quality functions and data privacy requirements
• Collect, coordinate and maintain essential documents and ensures the completeness of the Trial Master File (TMF) for assigned clinical studies
• Propose quality standards and oversee compliance;
• Respond to problems and assist in implementing corrective and preventive actions;
• Support the ongoing use of the CTMS
• Assist study staff and investigators to quickly and effectively resolve issues relating to Study Files.
• Contribute towards building new internal processes and systems within the clinical operations team to support the company’s growth
• Ensure inspection readiness

Education and Qualifications:
Bachelor’s degree or equivalent in life sciences or allied health fields such as nursing, pharmacy or health science.

Skills, Experience and Personal Attributes:
• Experience of either leading or involvement in the implementation of an eTMF system
• Experience of initiating, managing, running and maintaining an eTMF system
• Relevant clinical research experience in industry or in clinical practice as a trial/study coordinator
• Good understanding of GDPR and data privacy requirements
• Experience of working with patient tracking systems, financial tracking systems, archive document systems,
• Good understanding of how internal IT systems interface with external vendor systems
• Experience of working with current ICH/GCP guidelines
• Highly PC literate; able to learn and get up to speed with new IT systems as needed
• Good planning and organisational skills with strong attention to detail
• Good verbal and written communication skills
• Excellent team player
• Highly self-motivated with a “can do” attitude
• Positive and enthusiastic approach to work
• Flexible and able to respond to changing work priorities and mutli tasking
• Embraces change and happy to work in a growing and changing organisation

This is a permanent position, based in Stevenage with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Study Coordinator

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
An excellent opportunity has arisen for an experienced Study Coordinator to provide support and assistance in the set-up, organisation and management of clinical study projects ensuring compliance with SOPs and ICH-GCP. This role involves high utilisation of PC, Office-based software packages. The position will be office based, but the role holder may be required to undertake monitoring visits on occasions. The position offers high value and accelerated learning in the opportunity to experience cross functional aspects of the business and scientific data.

Responsibilities:
• Provide assistance with the set-up of studies working internally and externally to target timelines
• Assist the Clinical Project Manager with the day-to-day operational running of the study
• Support and oversee with the preparation and distribution of clinical trial supplies
• In conjunction with the clinical project manager provide support with the drafting of study documents and training material
• Occasionally undertake monitoring visits with CPMs or CRAs, when required, to assist the team
• Provide clinical trial and some administrative support on clinical programs as needed
• Prepare and oversee essential clinical trial documentation and distributing, tracking and filing documents
• To ensure the study documents are filed in the Trial Master File (TMF)with the clinical trial administrator in accordance with ICH-GCP and company SOPs. Undertake periodic checks on the completeness of the TMF
• To attend regular clinical and project team meetings, prepares meeting agendas and minutes plus maintains meeting action item lists.
• To provide assistance to the Quality Management team for their study including for any CAPA related to their study
• The post-holder will be responsible for adhering to all health and safety guidance, provided by the Company
• To support CPMs in programme related document finalization and contribute to in house self-assessment and quality of scientific data
• Any other ad-hoc tasks as required

This is an evolving role and the above list of responsibilities is not exhaustive; the post holder may be requested to assume additional duties, as might reasonably be required. This job description will be reviewed during the annual review process. As the company expands this role has the scope to contribute and manage supply and electronic systems for automation.

This position requires:
• Experience of working in Clinical Research or the Pharmaceutical Industry as a Clinical Research Associate or Junior Project Management or similar role is required
• Bachelor’s degree (BSc, BA or RN equivalent) in biological or science-related field preferred
• Experience in the set-up of clinical research studies
• Experienced in undertaking monitoring visits
• Good knowledge of the Industry/Clinical trial process
• Good knowledge of International Conference on Harmonisation (ICH) Good Clinical Practice guidelines (ICH-GCP)
• Self-motivated taking personal pride in delivering on personal and corporate objectives
• Able to interact with individuals at all levels of the organisation
• A highly effective communicator, both orally and in writing with an eye for detail and accuracy
• Strong organisational, time management and communication skills
• Ability to act on own initiative within inter-related team and meet deadlines
• Microsoft Office Skills – excellent proficiency in Word, Excel, PowerPoint and Outlook required
• Familiarity with use of eTMF is desirable

This is a permanent position, based in Stevenage with a competitive salary and benefits package.
Please send your CV with a covering letter by clicking Apply.

GCLP Research Associate

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal ne-oantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that pa-tient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking a scientist with experience working with human blood samples to join our growing company and support the development of a next generation personalised cancer medicine. As a GCLP Research Associate at Achilles Therapeutics, you will report directly to the Translational Science Princi-pal Scientist and work closely with other members of the team to receive, process and store follow-up samples from clinical trials at Achilles Therapeutics.
The successful candidate will have a role in sample receipt and processing, and in carrying out immunoassays. They will have experience working with human blood samples, including PBMC isolation and cell cryopreservation and in flow cytometry. Experience of working in accordance with GCLP or GxP guidelines would be of benefit.
If you want to be a part of a well-funded, exciting new start-up, and enjoy contributing to development of products which will transform the clinical management of cancer, then this is the role for you.

Responsibilities:
• Receive, process and bank human samples from Achilles clinical trials
• Complete all relevant documentation in accordance with GCLP guidelines
• Organising sample shipping between Achilles sites and to external vendors
• Carry out immunoassays including flow cytometry and ELISpot
• Maintain laboratory equipment as required
• Follow established SOPs
• Record sample and analysis data accurately

Essential experience:
• Undergraduate degree in a biological subject
• 2+ years hands-on laboratory experience
• Experience working with human blood samples, including PBMC isolation using density centrifugation
• Experience with immunoassays including flow cytometry
• Excellent planning, organisational and time management skills, and attention to detail
• Good communication and interpersonal skills
• Self-motivated with strong initiative and drive
• Ability to work flexibly, including evenings and weekends, as required
• Proficiency with MS Office

Desirable experience:
• Master’s degree in a relevant subject
• Experience working with liquid nitrogen
• Practical experience of working with a LIMS system
• Knowledge/experience of working in a GxP/GCLP environment
• Knowledge of cancer biology and immunology

This is a permanent position based at the Royal Free Hospital in London, with a competitive salary and benefits package to match experience. The company has laboratories in London and Stevenage UK.

Laboratory Assistant

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking an enthusiastic and organised team player to join our growing Process Development team and help support our busy laboratory. As Laboratory Assistant you will assist the Laboratory Manager with the routine running of the laboratory in order to maintain an efficient and productive working environment. Your work will involve preparation and aliquoting of reagents using an excellent aseptic technique, equipment maintenance and record keeping, shipping and tracking of samples, stock management using an online procurement system and other activities that will contribute to the smooth running of the laboratory.
This role would suit a candidate who has just finished a biology related degree and would like to gain experience in a lab environment. Prior experience is not necessary but a willingness to act as part of a team and the ability to take initiative are essential.

Responsibilities:
• General lab maintenance
• Regular maintenance, cleaning and record keeping of equipment
• Assisting the Lab Manager with stock management and ordering for the laboratory
• Assisting with document management and writing of standard operating procedures
• Assisting with Health & Safety in the laboratory
• Assisting with sample tracking
• Liaising with members of laboratory staff to organise shipping of samples
• Aliquoting reagents and performing batch qualifications
• Assisting other members of the lab team where necessary

Essential requirements:
• Undergraduate degree in a Biology related subject
• Excellent organisational and time management skills
• Good communication skills
• Attention to detail and precision
• Good interpersonal skills and the ability to work as part of a dynamic team
• Self-motivated with strong initiative
• Good knowledge of Microsoft Office
• Ability to work flexible hours including evenings or weekends if necessary

Desirable experience:
• Wet lab experience
• Aseptic technique training
• Presentation skills

This is a permanent position based at the SBC in Stevenage, with a competitive salary and benefits package to match experience. The company has laboratories in London and Stevenage UK.

GMP Production Scientist

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking a bright, enthusiastic and motivated GMP production scientist with experience in the field of Advanced Therapeutics Medicinal Products (ATMPs) to join our growing multi-disciplinary team and support the development of a next generation personalised cancer medicines. As a GMP production scientist you will support the technology transfer, validation and clinical production of Achilles Therapeutics ATMP pipeline within the CCGTT GMP clean rooms based at Royal Free Hospital and work closely with the product development team to support process engineering activities. If you want to be a part of a well-funded, exciting new start-up, and enjoy playing an active role in supporting the development and clinical manufacture of ATMPs which have the ability to transform the clinical management of cancer, then this is the role for you.

Responsibilities
• Support GMP activity for the manufacture of ATMPs to facilitate technology transfer, process validation, equipment validation and qualification, stability studies and materials management.
• Support process engineering activity in closed system cell culture and identifying and implementing procedures in accordance with GMP and regulatory standards.
• Support continued development and in-process improvement activity to streamline process operations and optimisation of manufacturing methods.
• Assist in the preparation and review of GMP documentation including BMRs, SOPs, Change Control, user requirement specifications, process deviations, and risk assessments to ensure the highest levels of controls and traceability.
• Perform ATMP manufacturing for clinical trials and ensure all manufacturing activities are undertaken in accordance with production requirements and GMP regulatory and quality standards.
• Assist in coordination of production scheduling activity, labelling, packaging and distribution of starting materials, raw materials and final drug product.
• Coordinate activities with QC to ensure appropriate and timely sampling and testing of raw materials, in-process samples and finished product.
• Be accountable to the head of production for all production operations.

Desirable Experience
• MSC in a Biological Science discipline.
• 5 years’ experience in a scientific laboratory role.
• 3 years’ experience working in a regulated environment (GLP/GCLP/GMP).
• Experience in human cell isolation, and cell and tissue culture in a GMP compliant environment.
• Able to work in a Grade B cleanroom production environment.
• ATMP Process development experience.
• Understanding of GMP, ATMP, and EUTCD regulations.
• Working knowledge of generating process and QC data for regulatory submissions.
• Strongly focused on quality and safety.
• Have excellent planning and organisational and time management skills.
• Have good communication and interpersonal skills.
• Self-motivated with strong initiative and drive.

This is a permanent position, with a competitive salary and benefits package to match seniority and experience. The company has laboratories in London and Stevenage UK.

Please send your CV with a covering letter by clicking Apply.

Translational Biostatistician

About Achilles Therapeutics: 

Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019. 

Role Summary: 

We are seeking an ambitious and skilled Translational Biostatistician to join our Translational Science team. This team is responsible for the development and delivery of analyses that turn exploratory hypotheses into actionable insights from our clinical trial data. 

This role within the Translational team at Achilles will be pivotal for delivering robust statistical analyses evaluating exploratory hypotheses in our Translational Science program. 

This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer. 

Responsibilities:  

The successful candidate will 

  • Help organise, model and integrate biological datasets from a variety of biological data sources (e.g. NGS, proteomics and IHC) to evaluate existing hypothesis and help guide the future direction of the Translational Science programme 
  • Work within the multidisciplinary Translational Science team; reporting and communicating results from analyses across the team and to the wider company 

This position requires:  

  • Recent PhD (or MSc and applicable work experience) in Statistics, or a numerate degree with a high component of statistical training 
  • In depth knowledge of statistical concepts and theory 
  • Demonstratable experience in handling, modelling and drawing inferences from large volumes of heterogenous datasets 
  • Authorship on high-quality papers in peer-reviewed journals
  •  Demonstrated fluency in either R or Python
  • Knowledge of UNIX based operating systems and prior use of computing clusters  
  • Very strong communication skills in order to convey statistical analyses and concepts 
  • Exceptional time management agility to deliver concurrent projects 
  • A clear ability to develop robust statistical analyses to fixed timescales 

 The following skills/experiences are desirable: 

  • Knowledge of Bayesian methodology, parameterisation and model comparison 
  • Prior experience in working in a clinical trials environment  

This is a permanent position, based in Stevenage, with a competitive salary and benefits package. 

Please send your CV with a covering letter by clicking Apply. 

 

Senior Bioinformatician

About Achilles Therapeutics:

Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking a highly talented and creative Senior Bioinformatician. The successful applicant will join a small team primarily focused on improving and developing methods to identify neoantigens. You will be expected to proficiently identify and benchmark published tools as well as contribute to the development of novel strategies. You will also design, implement, and apply statistical techniques to analyse and integrate large datasets and work in close collaboration with biologists and clinicians to interpret your analysis results.
This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

Responsibilities:
• Integration and exploratory data analysis of large, complex datasets
• Develop and test hypotheses whilst prototyping analytical approaches/models
• Develop scalable tools
• Effectively communicate analyses to a technical and non-technical audience

This position requires:
• PhD and 2+ years of relevant work experience in bioinformatics, computational biology, or equivalent
• Good knowledge of molecular genomics and immunology
• Knowledge of advanced statistical & machine learning concepts
• Practical experience of analysing next generation sequencing data (DNA and RNA)
• Authorship on high-quality papers in peer-reviewed journals
• Demonstrated fluency in R and Python
• Experience in reproducible research practices (e.g. dynamic documents, version control, containerization & workflow engines)
• Extensive knowledge of UNIX based operating systems

In addition to the above, you are expected to have:
• Exceptional communication skills
• Demonstrable excellence in problem solving within fixed timelines
• Flexibility and the ability to effectively manage multiple concurrent projects

In addition to the above, the following skills/experiences are desirable:
• Practical experience of oncogenomic, immunogenomic, neoantigen and/or TCR-seq analyses
• Practical experience with cloud-based technologies

This is a permanent position, based in Stevenage, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.