LIFE AT Achilles

At Achilles, we are focused on the development of the next generation of personalised immunotherapies to treat cancer and are dedicated to our patients, who desperately need breakthrough medicines.

We provide extraordinary career opportunities for talented individuals, who will have the opportunity to work with highly experienced leaders in science and business to build an exciting company at the very cutting edge of cancer medicine.

At Achilles you will enjoy a flexible and dynamic working environment that fosters creativity, leadership and teamwork. We offer benefits that include competitive salary and performance related bonus, group pension plan, life assurance, private medical insurance and employee share incentive scheme.

If you have what it takes to help build Achilles into a world class immune-oncology company and would like to become a part of our team, please contact: jobs@achillestx.com.

Achilles is an equal opportunity employer committed to a culturally diverse team.

Recruiters and agents must not forward CVs or candidate details to Achilles or any employee of the Company without an explicit, written request from a member of the HR department. We reserve the right to pursue and hire candidate(s) without any financial obligation to the recruiter if their details, which could reasonably identify them, have been passed to the Company without the explicit, written request of a member of the HR department. The agreement of terms in relation to a specific vacancy does not constitute an explicit request for applicants for other advertised roles or speculative applications.

What Our Team Say

I was attracted to Achilles by the ambition of the science that underlies Achilles’ goal. I enjoy the fast-paced environment of a start-up, encountering new challenges on a daily basis. Achilles has a multicultural and cohesive culture with a very strong sense of purpose.

Eleni Kotsiou

Principal Scientist, Process Development

I joined Achilles because I am interested in developing a cancer immunotherapy product with the aim of taking it to clinic. I really enjoy working within a multidisciplinary team and the variety in my role across process development and manufacturing.

Sam Jide-Banwo

GMP Production Scientist

Open PositionsAt Achilles

Project Manager – Supply Chain Systems

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

An exciting opportunity has arisen for a Project Manager to join the Supply Chain Operations Team. The role will form an integral part of the Supply Chain Operations team, providing cross-functional support to deliver supply chain automation.

The primary accountability of this role holder is to implement several integrated applications across the supply chain and the associated business change. This will involve coordinating multiple third party application vendors and ensuring that their solutions integrate with one another.

The successful applicant will require extensive experience of implementing multiple electronic systems, ideally in a pharmaceutical/CRO or healthcare setting. You will be working closely with IT consultants to design and deploy more complex system integrations, so some understanding of integration concepts and general technical knowledge is required. Business analyst and process mapping skills would be beneficial to deliver solutions which accurately reflect the business process.

Experience of working in cell and gene therapy will be advantageous. You will need to work with selected vendors and internal and external stakeholders to develop and implement a strategy for automated integration between systems without compromising the integrity of data.

Project management skills will be essential to ensure that projects are implemented according to agreed timelines and budget. As Achilles expands its operations globally the post holder will need to ensure the scalability of electronic systems and integration as well as contracting additional vendors as needed.

Key to the success of the role will be the ability to communicate effectively with internal and external stakeholders at various organisational levels and to work effectively together to implement system integration effectively.

This role would ideally suit someone with a business background who has knowledge and an interest in electronic systems. Ideally in a healthcare or pharmaceutical/CRO setting although candidates with experience from other industries will be considered.

This position requires:

  • Work with Supply Chain Operations Snr Manager and SVP Clinical Operations to plan strategy for electronic system deployment across the clinical supply chain
  • Ensure project deliverables are met according to agreed timelines and schedule and budget
  • Work with selected vendors to support system integration
  • Works with key contacts at clinical sites to ensure site level integration where necessary
  • Assist with vendor selection and provide service feedback for vendors
  • Ensure electronic systems are implemented in compliance with any relevant regulation
  • Work autonomously to develop agreed operational plans and deadlines, working with Achilles cross functions as needed
  • Contribute towards building new internal processes and systems
  • Attend regular project team meetings
  • Update CV and training records as required
  • Any other ad-hoc tasks as required
  • Responsible for adhering to all health and safety guidance provided by the company

This is as evolving role and the above list of responsibilities is not exhaustive; the post holder may be requested to assume additional duties, as might reasonably be required. This job description will be reviewed during the annual review process.

In addition to the above, the following skills/experiences are desirable:

  • Minimum of three-years’ experience of working in an electronic systems role, preferably in a healthcare setting or in the pharmaceutical/CRO industry
  • Experience of working on electronic system integration
  • Knowledge of COI and COC requirements in cell therapy (desirable)
  • Knowledge of cell therapy cell therapy processes e.g procurement, manufacture, logistics (desirable)
  • Knowledge of clinical research software solutions e.g. eTMF, eQMS, eBMR
  • Knowledge of techniques for establishing electronic system integration
  • Batchelor’s degree (BSc, BA or equivalent)
  • Experience of project management and proven track record of delivering according to agreed project timelines
  • High level of communication is essential (verbal and in writing); ability to communicate effectively within a healthcare and commercial setting
  • Ability to work effectively with external vendors ensuring key deliverables are met in line with projections
  • Good knowledge of ICH-GCP
  • Self-motivated taking personal pride in delivering on personal and corporate objectives
  • Able to interact effectively with individuals at all levels of the organisation
  • An eye for accuracy and good attention to detail
  • Strong organisational, time management and communication skills
  • Ability to act on own initiative within inter-related team and meet deadlines and dynamic turnaround requirements
  • Microsoft Office skills – excellent proficiency in Word, Excel, PowerPoint and Outlook required

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position, based in Hammersmith, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Research Associate

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

We are seeking a motivated, highly talented and creative Senior Scientist. The successful applicant will join a small team within the Process Development department primarily focused on the development of the new generations of T cell therapy products. As a research associate you will be expected to support process development activities.

The post requires a highly motivated, hard-working and organised individual with experience in immunology, cell culture techniques, multi-colour flow cytometry and immunoassays. Candidates with previous experience in cell therapies are encouraged to apply.

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Responsibilities:

  • Processing of tumour and blood samples from cancer patients.
  • Tissue culture of immune cells
  • Performing T cell functional assays and other immunoassays to characterise neoantigen reactive T cells
  • Flow cytometric data analysis.
  • Effectively communicate scientific results to a technical and non-technical audience
  • Generating suitable SOPs and following established SOPs

This position requires:

  • A BSc in cell biology, immunology or cancer
  • Knowledge of cancer immunology
  • Strong sense of urgency and ability to work in a fast-paced environment, excellent planning, organisational and time management skills, and attention to detail
  • Dependable individual and willing to take ownership and responsibility
  • Good communication and interpersonal skills

In addition to the above, the following skills/experiences are desirable:

  • Demonstrable excellence in problem solving within fixed timelines
  • Flexibility and the ability to effectively manage multiple concurrent projects

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position, based in initially based in Stevenage but relocating to West London in 2020 with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

QC Scientist (12 Month FTC)

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

We are seeking a bright, enthusiastic and motivated QC scientist ideally with hands on knowledge of working within a GCP/ GMP environment, to join our growing multi-disciplinary team on a 12-month Fixed Term Contract.  As part of the QC team you will support the validation and clinical production of Achilles Therapeutics ATMP pipeline at the Royal Free Hospital site and work closely with the GMP manufacturing team and product development team to support the development of next generation personalised cancer medicines. If you want to be a part of a well-funded, exciting new start-up, and enjoy playing an active role in supporting the development and clinical manufacture of ATMPs which have the ability to transform the clinical management of cancer, then this is the role for you.

Responsibilities:

  • Carrying out QC testing of raw materials, in process controls, and finished product, in line with GMP regulations.
  • To assist in the preparation and review of documentation including SOPs and risk assessments to ensure the highest levels of controls and traceability.
  • Assist in the design and validation of immune monitoring assays using flow cytometry and ELISpot.
  • Perform maintenance and calibration of laboratory equipment including flow cytometers.
  • Help train other team members
  • Be accountable to the Principal QC Scientist.

This position requires:

  • 3 years’ experience in a scientific laboratory role
  • Understanding of GCP guidelines
  • Experience in aseptic technique for cell and tissue culture
  • 3 years’ Experience in flow cytometry
  • Strongly focused on quality and safety
  • Contribute to a culture that embraces scientific excellence, integrity, urgency, and continuous improvement
  • Have excellent planning and organisational and time management skills
  • Have good communication and interpersonal skills

In addition to the above, the following skills/experiences are desirable:

  • Experience in assay validation
  • Experience working in a GCP/GMP regulated environment
  • Self-motivated with strong initiative and drive

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a 12-month Fixed Term Contract based in the Royal Free Hospital in London, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Deputy LIMS Administrator

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

Achilles Therapeutics is looking for an experienced Data Manager to join our Manufacturing team. This team is responsible for the GMP production and quality control (QC) testing of our cellular therapies. The Data Manager role at Achilles will be crucial for ensuring data integrity from the management of QC laboratory activities through to the processing and reliable storage of data outputs for trending analyses. The initial focus of the set-up and implementation of the LIMS for the Manufacturing team. If you want to be a part of a well-funded, exciting new start-up, and enjoy playing an active role in supporting the development and clinical manufacture of ATMPs which have the ability to transform the clinical management of cancer, then this is the role for you.

Responsibilities:

  • Support the administration and configuration of the LabWare LIMS system to aid sample, material and equipment management and recording of outputs from Manufacturing activities.
  • Responsible for implementing and maintaining laboratory instrument interfaces with LIMS.
  • Responsible for the generation and management of information stored in LIMS to support statistical analysis, interpretation of data, and investigating causes.
  • Co-ordinating data output from different QC assays through the data lifecycle to ensure reliable insertion into Achilles’ proprietary databases and data integrity

This position requires:

  • BSc or MSc in Computer Science or a relevant informatics subject
  • Experience in the LabWare LIMS
  • Demonstrated fluency in a general programming language (Python)
  • Understanding and experience of Relational Databases and SQL
  • Experience of handling biological datasets

Preferred but not essential experience:

  • Experience in the validation of computer software to GMP standards
  • Experience in organising and transferring large volumes of data securely and robustly

In addition to the above, the following skills/experiences are desirable:

  • Strong organisational skills and a desire to take responsibility for all aspects of the data lifecycle
  • Commitment to championing data integrity.
  • Passion for processing and delivering clean data for downstream analyses
  • Exceptional time management agility to manage concurrent data flows
  • Excellent communication skills and the ability to work cross-functionally

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position based in Stevenage, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Clinical Operations Project Manager, US

Location: Philadelphia, US  

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

You will be joining a growing and well-funded, London based, biotech company which is developing next generation cell therapies for oncology indications. You would become one of the leaders and establish US operations, working as part of a close knit and results driven team. Ideal for an established PM from biotech who has worked through the CRA route with oncology and cell therapy experience from Biotech.

This position requires:

Play a pivotal role as an early hire in our US Clinical Operations team leading clinical operations for studies within a programme. In conjunction with the head of clinical operations you will be a key role for US operations. Act as an expert in your therapy area, working independently with vendors/partners and then supported as necessary based on an individual development plan.

This position will have key relationships with internal stakeholders within the clinical project team and will have clearly defined responsibilities working alongside the Head of US clinical operations, as well as externally with KOLs, investigators and external service providers/vendors.

  • Create/Review patient consent forms and provide relevant opinion
  • Review CTAs with Vendors and sites, and provide relevant feedback
  • Have responsibility for oversight and delivery of components of clinical trials and data generation
  • Serve as a close partner to the study physicians, co-ordinating the activity of a research team and holding full accountability for projects, often with global impact
  • The overall efficient day-to-day clinical trial management of studies
  • Liaise with vendors for RFIs and RFPs, and involvement in vendor selection activities
  • Manage and support start up activities for US clinical trials sites including negotiation of contracts, site selection and review of essential regulatory documentation
  • Manage timeline adherence, site budget adherence in conjunction with the Head of Clinical Operations or designee and project quality deliverables
  • Review and provide input to study protocols
  • Interact with and day to day management of vendors including supporting Head of Clinical Operations with vendor budget oversight
  • Oversight of various vendors activities
  • Manage contract requirements
  • Perform on site visits as required to ensure corporate deliverables
  • Occasional interim monitoring visits, including site qualification, initiation and close-out, including the source data verification of CRFs and Data clarification forms as stipulated
  • If required review the preparation and publication of data, reports and information, ensuring that these meet legislative, contractual and ethical requirements
  • To maintain Project documents in accordance with ICH-GCP and company SOPs and support the transition from paper to eTMF
  • Develop and update study plans and documents, including the Project Plan, Monitoring Plan, Deviation Plan
  • Support the review and development of department SOPs in conjunction with the Head of US clinical operations
  • Support the hiring and mentorship of other members of the Clinical Operations team, for example CRAs or CTAs
  • Review of site monitoring reports when as required
  • Provide site study training and internal training to the clinical ops team as required
  • Collaborate with site teams and CRAs to drive recruitment and high-quality data collection
  • Prepares and support material preparation for external meetings, other study trainings and project meetings as required
  • Willingness to travel nationally and on occasionally internationally for the role
  • Any other ad-hoc tasks as required including general support to the Head of Clinical Operations
  • The incumbent will be responsible for adhering to all health and safety guidance, provided by the Company and US specific requirements
  • Knowledgeable in FDA guidelines and requirements
  • Ability to multitask and deliver under pressure

Demonstrated skills and competencies:  

  • Minimum of 7 years clinical trial experience with minimum 2 years’ experience in a senior or lead role
  • Strong clinical study experience in cell or advanced therapy.
  • Previous experience of site monitoring in early phase oncology studies ideally in melanoma or NSCLC
  • Excellent collaboration and communication skills.
  • Adept at partnering with a diverse team and delivering results through taking ownership of key programme components.
  • Strong clinical, technical or disease area expertise.
  • ICH GCP trained.

Qualifications: 

  • Bachelor’s degree (BSc, BA or RN equivalent) in biological or science-related field is essential

Skills/Specialist knowledge:

  • Ability to establish and maintain effective working relationships with co-workers, managers, investigator site personnel and service providers.
  • Thorough knowledge of ICH-GCP guidelines and UK legislation.
  • Excellent communication, interpersonal and organisational skills.
  • Effective problem-solving skills.
  • Attention to detail and timelines.
  • Computer literacy, proficiency in Microsoft Office.
  • Ability to work independently and to effectively prioritise tasks

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position, located Philadelphia, US, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

 

GCLP Research Scientist, Translational Sciences

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

We are seeking a bright, motivated and highly organised GCLP Scientist to join our growing company to support the development of a next generation personalised cancer medicine. As GCLP Scientist at Achilles Therapeutics, you will work as part of the Translational Science team to carry out immune monitoring assays for follow-up of clinical trial patients.

The ideal candidate will have experience of working and in a Good Clinical Laboratory Practice (GCLP) laboratory or in accordance with GCLP guidelines.

If you want to be a part of a well-funded, exciting new start-up and enjoy contributing to development of products which will transform the clinical management of cancer, then this is the role for you.

This position requires:

  • Coordinate characterisation and analysis of Achilles’ clinical trial products
  • Carry out immunoassays on clinical trial samples to support the Translational Science labs team.
  • Prepare documentation, including Change Controls and Q&V documents, according to GCLP and Achilles QMS guidelines.
  • Design and perform assay development/optimisation and qualification for immune monitoring assays to be performed on follow-up clinical trial samples.
  • Contribute towards set up of GCLP laboratory at new Translational labs, including equipment validation and routine monitoring.

Essential experience:

  • Experience working with human T Cell culture
  • Knowledge of cancer biology or immunology
  • Experience working in a GCLP laboratory or according to GCLP guidelines
  • Flow cytometry experience
  • Proficiency with MS Office
  • Excellent planning and organisational and time management skills
  • Good communication and interpersonal skills
  • Ability to work flexibly including evenings and weekends, as required

In addition to the above, the following skills/experiences are desirable:

  • An understanding of Human Tissue Authority legislation
  • Experience working with a LIMS system

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position based across Achilles Sites in London, with a competitive salary and benefits package to match seniority and experience. The company has laboratories in London and Stevenage UK.

Please send your CV with a covering letter by clicking Apply.

Senior Scientist, Immune Monitoring

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

We are seeking a bright, motivated and highly organised Senior Scientist with experience in immunological laboratory techniques and flow cytometry. As Senior Scientist at Achilles Therapeutics, you will work as part of the Translational Science team and support the team’s efforts to further optimise and develop different immune assay for immune monitoring of clinical trial patients. You will also work closely with members of the Translational Science and Manufacturing teams to carry out and organise assays on human samples from clinical trials at Achilles Therapeutics.

The ideal candidate will have experience of working and in a Good Clinical Laboratory Practice (GCLP) laboratory or in accordance with GCLP guidelines.

If you want to be a part of a well-funded, exciting new start-up and enjoy contributing to development of products which will transform the clinical management of cancer, then this is the role for you.

This position requires:

  • Design,optimise and validate immunoassays including multi-parameter flow cytometry and ELISpot for clinical trial samples
  • Prepare documentation, including Change Controls and Q&V documents, according to GCLP and Achilles QMS guidelines.
  • Support the flow cytometry capabilities across Achilles sites.
  • Support the setting up of new Translational Science laboratories in London
  • Coordinate characterisation and analysis of Achilles’ clinical trial products

Essential experience:

  • PhD in immunology
  • Strong lab experience
  • Demonstrated experience working to GCLP or GxP requirements
  • Practical experience with immunoassays including multi-parameter flow cytometry
  • Assay optimisation
  • Ability to work flexibly including evenings and weekends, as required

In addition to the above, the following skills/experiences are desirable:

  • Assay qualification and validation experience
  • Writing and reviewing SOPs to GCLP standard
  • Practical experience of working with and/or set up of a LIMS system
  • Working knowledge of Human Tissue Authority legislation

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position based across Achilles Sites in London, with a competitive salary and benefits package to match seniority and experience. The company has laboratories in London and Stevenage UK.

Please send your CV with a covering letter by clicking Apply.

 

GCLP Senior Scientist, Translational Sciences

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

We are seeking a bright, motivated and highly organised Senior GCLP Scientist with experience of working to GxP to join our growing company to support the development of a next generation personalised cancer medicine. As Senior GCLP Scientist at Achilles Therapeutics, you will work as part of the Translational Science team to carry out immune monitoring assays for follow-up of clinical trial patients

The successful candidate will drive the set-up of new Translational Science Laboratories at Achilles expansion sites together with other members of the Achilles team, including managing change control and qualification and validation (Q&V) of new facilities and equipment. You will also work closely with members of the Translational Science and Manufacturing teams to carry out and organise assays on human samples from clinical trials at Achilles Therapeutics.

The ideal candidate will have experience of working and in a Good Clinical Laboratory Practice (GCLP) laboratory or in accordance with GCLP guidelines.

If you want to be a part of a well-funded, exciting new start-up and enjoy contributing to development of products which will transform the clinical management of cancer, then this is the role for you.

This position requires:

  • Drive the set up new Translational Science laboratories in London according to GCLP guidelines together with other Achilles members of staff.
  • Support implementation of GCLP system across Achilles sites.
  • Prepare documentation, including Change Controls and Q&V documents, according to GCLP and Achilles QMS guidelines.
  • Oversee validation and maintenance of laboratory equipment.
  • Coordinate characterisation and analysis of Achilles’ clinical trial products
  • Carry out immune monitoring assays including multi-parameter flow cytometry and ELISpot on clinical trial samples

Essential experience:

  • Master’s/Postgraduate degree in a relevant subject
  • Experience working in both academia and industry is essential
  • Demonstrated experience of working to GCLP or GxP standards
  • Excellent planning, organisational and time management skills, and attention to detail
  • Good communication and interpersonal skills
  • Self-motivated with strong initiative and drive
  • Ability to work flexibly including evenings and weekends, as required

In addition to the above, the following skills/experiences are desirable:

  • Master’s/Postgraduate degree in a relevant subject
  • Knowledge of cancer biology and immunology
  • An understanding of Human Tissue Authority legislation
  • Experience working with a LIMS system
  • Experience of immunology assays, including Flow Cytometry and ELISpot

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position based at Hammersmith in London, with a competitive salary and benefits package to match seniority and experience. The company has laboratories in London and Stevenage UK.

Please send your CV with a covering letter by clicking Apply.

Senior Scientist, Product Characterisation

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

We are seeking a bright, motivated and highly organised scientist with experience in immunological laboratory techniques, to join our growing company and support the development of a next generation personalised cancer medicine. As a Senior Scientist at Achilles Therapeutics, you will report directly to the Team Leader of Product Characterisation and support the team’s efforts to analyse T cell products derived from our first two clinical trials by leading a small sub team of junior lab staff. You will work closely with other members of the Translational Science, Product Development, QC and Manufacturing teams to further optimise immune assays, transfer them to other departments and organise clinical trial samples across the different Achilles Therapeutics sites.

If you want to be a part of a well-funded, exciting new start-up, and enjoy contributing to development of products which will transform the clinical management of cancer, then this is the role for you.

This position requires:

  • Coordinate characterisation and analysis of Achilles’ clinical trial products
  • Carry out immunoassays including T cell culture, multi-parameter flow cytometry and ELISpot on clinical trial samples
  • Support the setting up of the Translational Science team at Stevenage
  • Lead small sub team of junior lab staff
  • Complete all relevant documentation in accordance with GCLP guidelines
  • Design new SOPs and worksheets and follow established SOPs
  • Design and optimise assays that characterise Achilles’ cNeT product

Essential Experience:

  • PhD in immunology
  • At least 5 years laboratory experience post PhD
  • Industry or CRO experience
  • Experience working in a GCLP or GxP environment
  • Practical experience in human primary T cell culture
  • Practical experience with immunoassays including multi-parameter flow cytometry
  • Writing and reviewing of SOPs
  • Assay optimisation
  • Excellent planning, organisational and time management skills
  • Attention to detail
  • Team Player: Ability to learn from senior and junior members of the team
  • Good communication and interpersonal skills
  • Self-motivated with strong initiative and drive
  • Ability to work flexibly including evenings and weekends, as required
  • Proficiency with MS Office

In addition to the above, the following skills/experiences are desirable:

  • Practical experience in ELISpot assay
  • High-dimensional flow cytometry analysis experience
  • Assay qualification and validation experience
  • Writing and reviewing SOPs to GCLP standard
  • Practical experience of working with and/or set up of a LIMS system
  • Working knowledge of HTA

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position based at Stevenage Bioscience Catalyst in Hertfordshire.

The role offers a competitive salary and benefits package to match experience.

Please send your CV with a covering letter by clicking Apply.

Junior Project Manager

About Achilles Therapeutics:

Achilles Therapeutics is a clinical stage biopharmaceutical company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies and have two programs in the clinic for the treatment of Non-Small Cell Lung Cancer and Melanoma.

Role Summary:

You will be joining a growing, London based, biotech company which is developing neo-antigen therapy for oncology indications. You would become one of the leaders within their close-knit team, responsible for coordinating and managing allocated studies.  Ideal for a LCRA, UK CTM or aCPM/jCPM making the transition into global cell therapy from Pharma or Biotech who already has oncology and/or cell therapy experience.

This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Play a pivotal role in our Clinical Operations team leading clinical studies within a programme.  Act as an expert in your therapy area, working independently and then supported as necessary based on an individual development plan.

This position will have key relationships with internal stakeholders within the clinical project team and will have clearly defined responsibilities working alongside the senior clinical team, as well as externally with KOLs, investigators and external service providers/vendors.

This position requires:

  • Create/review patient consent forms and provide relevant opinions
  • Have responsibility for delivery of components of assigned global clinical trials
  • The overall efficient day-to-day clinical trial management of studies
  • Oversight of data collection and key milestones
  • Manage and support activities for clinical trials sites including negotiation of contracts, site selection (where required) and review of essential regulatory documentation
  • Manage timeline adherence, site budget adherence in conjunction with the Clinical Team and project quality deliverables
  • Interact with and day to day management of vendors including supporting with vendor budget oversight
  • Manage contract requirements
  • Co-ordinate the preparation and publication of data, reports and information, ensuring that these meet legislative, contractual and ethical requirements
  • To maintain Project documents in accordance with ICH-GCP and company SOPs and eTMF
  • Develop and update with oversight of senior team study plans and documents, including the Project Plan, Monitoring Plan, Deviation Plan
  • Collaborate with site teams and CRAs to drive patient recruitment and retention and high quality data collection
  • Prepares and support material preparation for external meetings, other study trainings and project meetings as required
  • Be prepared to travel internationally for the role

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

This is a permanent position, based in Hammersmith, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.