LIFE AT Achilles

At Achilles, we are focused on the development of the next generation of personalised immunotherapies to treat cancer and are dedicated to our patients, who desperately need breakthrough medicines.

We provide extraordinary career opportunities for talented individuals, who will have the opportunity to work with highly experienced leaders in science and business to build an exciting company at the very cutting edge of cancer medicine.

At Achilles you will enjoy a flexible and dynamic working environment that fosters creativity, leadership and teamwork. We offer benefits that include competitive salary and performance related bonus, group pension plan, life assurance, private medical insurance and employee share incentive scheme.

If you have what it takes to help build Achilles into a world class immune-oncology company and would like to become a part of our team, please contact: jobs@achillestx.com.

Achilles is an equal opportunity employer committed to a culturally diverse team.

Strictly no Agencies. Please note that Achilles Therapeutics does not accept speculative applications from recruitment agencies.

What Our Team Say

I was attracted to Achilles by the ambition of the science that underlies Achilles’ goal. I enjoy the fast-paced environment of a start-up, encountering new challenges on a daily basis. Achilles has a multicultural and cohesive culture with a very strong sense of purpose.

Eleni Kotsiou

Principal Scientist, Process Development

I joined Achilles because I am interested in developing a cancer immunotherapy product with the aim of taking it to clinic. I really enjoy working within a multidisciplinary team and the variety in my role across process development and manufacturing.

Sam Jide-Banwo

GMP Production Scientist

Open PositionsAt Achilles

GMP Production Scientist

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking a bright, enthusiastic and motivated GMP production scientist with experience in the field of Advanced Therapeutics Medicinal Products (ATMPs) to join our growing multi-disciplinary team and support the development of a next generation personalised cancer medicines. As a GMP production scientist you will support the technology transfer, validation and clinical production of Achilles Therapeutics ATMP pipeline within the CCGTT GMP clean rooms based at Royal Free Hospital and work closely with the product development team to support process engineering activities. If you want to be a part of a well-funded, exciting new start-up, and enjoy playing an active role in supporting the development and clinical manufacture of ATMPs which have the ability to transform the clinical management of cancer, then this is the role for you.

Responsibilities
• Support GMP activity for the manufacture of ATMPs to facilitate technology transfer, process validation, equipment validation and qualification, stability studies and materials management.
• Support process engineering activity in closed system cell culture and identifying and implementing procedures in accordance with GMP and regulatory standards.
• Support continued development and in-process improvement activity to streamline process operations and optimisation of manufacturing methods.
• Assist in the preparation and review of GMP documentation including BMRs, SOPs, Change Control, user requirement specifications, process deviations, and risk assessments to ensure the highest levels of controls and traceability.
• Perform ATMP manufacturing for clinical trials and ensure all manufacturing activities are undertaken in accordance with production requirements and GMP regulatory and quality standards.
• Assist in coordination of production scheduling activity, labelling, packaging and distribution of starting materials, raw materials and final drug product.
• Coordinate activities with QC to ensure appropriate and timely sampling and testing of raw materials, in-process samples and finished product.
• Be accountable to the head of production for all production operations.

Desirable Experience
• MSC in a Biological Science discipline.
• 5 years’ experience in a scientific laboratory role.
• 3 years’ experience working in a regulated environment (GLP/GCLP/GMP).
• Experience in human cell isolation, and cell and tissue culture in a GMP compliant environment.
• Able to work in a Grade B cleanroom production environment.
• ATMP Process development experience.
• Understanding of GMP, ATMP, and EUTCD regulations.
• Working knowledge of generating process and QC data for regulatory submissions.
• Strongly focused on quality and safety.
• Have excellent planning and organisational and time management skills.
• Have good communication and interpersonal skills.
• Self-motivated with strong initiative and drive.

This is a permanent position, with a competitive salary and benefits package to match seniority and experience. The company has laboratories in London and Stevenage UK.

Please send your CV with a covering letter by clicking Apply.

Talent Acquisition Specialist

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking a Talent Acquisition Specialist. The main purpose of the role is to source, attract, and recruit talented individuals into the company in an efficient and cost-effective way. Achilles is at an inflection point in its growth plan and the Specialist will be a key enabling role that facilities this ambitious build out with anticipated headcount growth of 60 to 300 over the coming 5 years.
Achilles operates within a competitive recruitment environment being in both the advance therapy and oncology space and the Specialist must be able to drive innovative recruitment practices that secures exceptional talent for an exceptional Company.

Responsibilities and Duties:
• Develop an in-depth understanding of Achilles and its business activities enabling the candidate to represent the Achilles appropriately in the market
• Use creative sourcing techniques to build an effective pipeline which identifies and engages both active and passive candidates through a blend of recruitment methods, including social media, headhunting, job boards, referrals and networking
• For hard-to-fill or senior vacancies, agencies may remain the most appropriate route. For these vacancies the preferred agency suppliers list will be refined with appropriate terms negotiated if not already in place and the ongoing relationship managed. For active hiring provide clear guidance regarding the role to the agency, collect timely feedback and efficient coordination
• Work with department heads to develop role profiles for vacant positions and agree interview process with the department head
• Manage a high quality end to end candidate experience with the assistance of the Achilles administrative function
• Manage and track incoming CVs, conduct initial screening and liaise with hiring managers to select and setup interviews
• Lead the interviewing process, interview candidates, gather feedback from others, liaise with the hiring manager to reach final selection and negotiate the offer subject to approved budget limits
• Once offer is accepted, ensure offer letter and contract is prepared in a timely fashion and ensure references are taken. *
• Oversee onboarding and induction process. *
• Track all recruitment activity to monitor response times, cost, and enable appropriate reporting.
• Perform quarterly reviews of the recruitment process.
• Ensure that the recruitment budget is managed efficiently by transitioning away from an agency-reliant model to a model where candidates are largely sourced direct.
• Keep abreast of relevant recruitment legislation including GDPR, considering its impact on the company’s recruitment strategy and activities and suggest appropriate action.
*These activities are carried out by an administrator, but the Talent Acquisition Specialist will be responsible for ensuring quality and timeliness of these activities.

Education and Qualifications
• Degree qualified or equivalent. Life Sciences degree desirable.
• Experience of having worked in a pharmaceutical, biotech or pharma services environment essential, ideally with both large and SME experience
• Significant experience in recruitment, gained in in-house roles as part of a recruitment team or an HR function. Experience gained in a recruitment agency environment would be advantageous
• Experience of having led the recruitment of a wide range of roles, from entry level to management level

Skills and Personal Attributes
• Ability to work on a number of different roles at one time and work to tight deadlines
• Excellent research and sourcing skills
• Clear sense of urgency, drive and determination
• Intuitive and good at assessing and reading individuals
• Excellent interpersonal and communication skills
• Diplomatic, natural ambassador for the Company, able to influence and sell the opportunity
• Fluent in the use of industry standard channels such as LinkedIn, job boards, and be adept at utilising a variety of marketing channels to advertise and source new talent.
• Highly organised and able to coordinate and organise others
• Good networker
• Creative
• Willing to travel

We are flexible whether this is a permanent or interim position. It is based in Stevenage, with a competitive salary and benefits package.
Please send your CV with a covering letter by clicking Apply.

Translational Biostatistician

About Achilles Therapeutics: 

Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019. 

Role Summary: 

We are seeking an ambitious and skilled Translational Biostatistician to join our Translational Science team. This team is responsible for the development and delivery of analyses that turn exploratory hypotheses into actionable insights from our clinical trial data. 

This role within the Translational team at Achilles will be pivotal for delivering robust statistical analyses evaluating exploratory hypotheses in our Translational Science program. 

This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer. 

Responsibilities:  

The successful candidate will 

  • Help organise, model and integrate biological datasets from a variety of biological data sources (e.g. NGS, proteomics and IHC) to evaluate existing hypothesis and help guide the future direction of the Translational Science programme 
  • Work within the multidisciplinary Translational Science team; reporting and communicating results from analyses across the team and to the wider company 

This position requires:  

  • Recent PhD (or MSc and applicable work experience) in Statistics, or a numerate degree with a high component of statistical training 
  • In depth knowledge of statistical concepts and theory 
  • Demonstratable experience in handling, modelling and drawing inferences from large volumes of heterogenous datasets 
  • Authorship on high-quality papers in peer-reviewed journals
  •  Demonstrated fluency in either R or Python
  • Knowledge of UNIX based operating systems and prior use of computing clusters  
  • Very strong communication skills in order to convey statistical analyses and concepts 
  • Exceptional time management agility to deliver concurrent projects 
  • A clear ability to develop robust statistical analyses to fixed timescales 

 The following skills/experiences are desirable: 

  • Knowledge of Bayesian methodology, parameterisation and model comparison 
  • Prior experience in working in a clinical trials environment  

This is a permanent position, based in Stevenage, with a competitive salary and benefits package. 

Please send your CV with a covering letter by clicking Apply. 

 

Bioinformatics Software Engineer (full time)

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking a talented and enthusiastic team player to support the robust implementation of features in our bioinformatics software pipeline arising from research findings. This software is a highly specialised pipeline focused on the identification of neo-antigens from high-throughput DNA sequencing data to direct the development of targeted immunotherapies in cancer.
The successful candidate will possess the ability to take initiative, a desire to work in a dynamic fast paced team environment and an ability to manage multiple, concurrent projects. Prior bioinformatics experience is not required, but a willingness to learn is essential.
This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

This position requires:
• BSc or MSc qualification in Computer Science, Bioinformatics or a related technical field or equivalent practical experience
• Expertise with at least one programming language
• Experience working within a Linux command-line environment
• Ability and willingness to rapidly learn new languages/frameworks as required
• Excellent communication skills
• A disciplined attitude towards developing robust, reliable and maintainable code

In addition to the above, the following skills/experiences are desirable:
• Experience with Git
• Experience with scripting languages such as python or R
• Groovy (or Java) experience
• Strong knowledge of Bash
• Hands-on experience with high-throughput DNA sequencing data

This is a permanent position, based in Stevenage, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Innovation Funding Specialist

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking a well-qualified and experienced candidate to join our growing multi-disciplinary team at Achilles Therapeutics to lead and coordinate the development of high-quality funding proposals to UK, EU and global funders as well as to manage the post-award grant reporting requirements.

Responsibilities:
• Track the funding landscape for upcoming opportunities that are relevant to the company
• Proactively highlight the opportunities to senior management to allow ample planning and preparation time
• Develop knowledge on each of the company’s functions to match their funding ideas and projects with relevant funding opportunities
• Maintain internal database for identified funding opportunities as well as funded projects to track their progression
• Work with the different functions on the preparation of funding applications – help with technical content and the writing of non-specialist sections, structure and presentation, advise and prepare costings, and ensure the application meets the objectives and priorities of the funder and the scheme
• For collaborative schemes, assist with identifying partners and liaise and coordinate with partner organisations to obtain information as well as content for the proposal
• Develop relationships with the different funders to understand their current and future priorities, application process and terms and conditions
• Handle the post-award reporting requirements to the funders including submitting technical/programmatic reports in a timely fashion
• Liaise with Finance to generate budget forecasts and track expenditure for each award
• Any other ad-hoc tasks as required
• The post-holder will be responsible for adhering to all health and safety guidance, provided by the Company

This is an evolving role and the above list of responsibilities is not exhaustive; the post holder may be requested to assume additional duties, as might reasonably be required. This job description will be reviewed during the annual review process.

This position requires:
• Experience in coordinating, preparing and writing successful funding proposals
• Experience in leading projects and managing internal and external stakeholders
• Strong knowledge of UK, EU and global funders and relevant funding mechanisms
• Strong understanding of pharmaceutical R&D in oncology and/or cell therapy
• PhD degree in biological or science-related field preferred
• Self-motivated taking personal pride in delivering on personal and corporate objectives
• Able to interact with individuals at all levels of the organisation
• A highly effective communicator, both orally and in writing with an eye for detail and accuracy
• Strong organisational, time management and communication skills
• Strong analytical skills
• Ability to act on own initiative within inter-related team and meet deadlines
• Microsoft Office Skills – excellent proficiency in Word, Excel, PowerPoint and Outlook required

This is a permanent position, based in London, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Cell Therapy Operations Project Manager

About Achilles Therapeutics:
Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking a well-qualified and experienced candidate to join our growing multi-disciplinary team at Achilles Therapeutics to support the delivery of the Company’s personalised cell therapy product that is entering the clinic later this year in a phase I/II trial. The Cell Therapy Operations Project Manager will be responsible for planning, tracking, management and communicating activities across the Manufacturing, Quality Control and Process Development functions. This will include working with contract testing organisations, collaborators, logistics partners, internal stakeholders and strategic partners. In addition, the role will include responsibility for overseeing the project management of expanding Achilles future manufacturing capabilities.
This is a unique opportunity to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.

Responsibilities:
• Document and track operational deliverables for CMC timelines
• Lead CMC communications for operational activity to internal stakeholders
• Serve as a primary point of contact with external collaborators on all CMC activities
• Facilitate contingency planning and problem solving to ensure maintenance of CMC timelines
• Co-ordinate and oversee the transfer of the Company’s technology into newly identified GMP facilities
• Organise and chair regular CMC project management meetings
• Work closely with SVP Manufacturing and Head of GMP Production to support operational delivery of CMC milestones

This position requires:
• Proven experience in the biotech/pharma industry working within project management in a CMC function
• MSc or BSc in biological sciences
• Proven relationship management of collaborators and contract testing organisations
• Experience of working within a GMP environment preferably in cell and gene therapy
• Experience of regulatory landscape for advanced therapies
• Excellent interpersonal and organisation skills
• Ability to work under pressure, prioritise and operate in a fast-paced environment
• Outstanding team player

This is a permanent position, based across London and Stevenage with a competitive salary and benefits package.
Please send your CV with a covering letter by clicking Apply.

Senior Bioinformatician

About Achilles Therapeutics:

Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:
We are seeking a highly talented and creative Senior Bioinformatician. The successful applicant will join a small team primarily focused on improving and developing methods to identify neoantigens. You will be expected to proficiently identify and benchmark published tools as well as contribute to the development of novel strategies. You will also design, implement, and apply statistical techniques to analyse and integrate large datasets and work in close collaboration with biologists and clinicians to interpret your analysis results.
This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to become a key contributor to an exciting project destined to change the course of cancer patient management in the clinic.

Responsibilities:
• Integration and exploratory data analysis of large, complex datasets
• Develop and test hypotheses whilst prototyping analytical approaches/models
• Develop scalable tools
• Effectively communicate analyses to a technical and non-technical audience

This position requires:
• PhD and 2+ years of relevant work experience in bioinformatics, computational biology, or equivalent
• Good knowledge of molecular genomics and immunology
• Knowledge of advanced statistical & machine learning concepts
• Practical experience of analysing next generation sequencing data (DNA and RNA)
• Authorship on high-quality papers in peer-reviewed journals
• Demonstrated fluency in R and Python
• Experience in reproducible research practices (e.g. dynamic documents, version control, containerization & workflow engines)
• Extensive knowledge of UNIX based operating systems

In addition to the above, you are expected to have:
• Exceptional communication skills
• Demonstrable excellence in problem solving within fixed timelines
• Flexibility and the ability to effectively manage multiple concurrent projects

In addition to the above, the following skills/experiences are desirable:
• Practical experience of oncogenomic, immunogenomic, neoantigen and/or TCR-seq analyses
• Practical experience with cloud-based technologies

This is a permanent position, based in Stevenage, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.