Pipeline

Achilles Pipeline

Our lead product is a precision tumor-derived T cell therapy targeting clonal cancer neoantigens. Our lead indications, advanced non-small cell lung cancer and recurrent metastatic melanoma, were selected for their high mutational burden, high level of T cell infiltration and high unmet medical need. Deaths from non-small cell lung cancer outnumber those resulting from breast cancer, colon cancer and prostate cancer combined, and there are limited approved treatment options for lung cancer and melanoma patients whose disease has not responded well to other therapies.

A scientist using a pipette
Disease
Research & Preclinical Development
Phase 1/2
Pivotal
CHIRON: Advanced Non-Small Cell Lung Cancer (Monotherapy)
THETIS: Melanoma (Monotherapy)
THETIS: Melanoma (PD-1 Combination)
Other Combinations
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An Open-Label, Multi-Centre Phase I/IIa Study Evaluating the Safety and Clinical Activity of Neoantigen Reactive T cells in Patients with Advanced Non-Small Cell Lung Cancer
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An Open-Label, Multi-Centre Phase I/IIa Study Evaluating the Safety and Clinical Activity of Neoantigen Reactive T cells in Patients with Metastatic or Recurrent Melanoma